王维蓉，教授，博士生导师
研究领域
1. 心血管疾病发生发展机制
2. 心血管疾病表观遗传学调控
3. 心血管疾病药物治疗
► 招收病理学与病理生理学专业的硕士和博士研究生。
► 招收药学专业硕士研究生。
► 招收与医学、药学、护理、生物医学等相关学科的推免生。
工作简历
2024.1-至今，教授，西安交通大学
2019.7-至今，博士生导师，西安交通大学
2017.4-2023.12，副教授、西安交通大学
2016.2-2017.2，访问学者，病理系，美国华盛顿大学
2013.7-2017.3，讲师，西安交通大学
2009.9-2013.6，博士，药理学，西安交通大学
学术科研
先后主持国家及省部级、校级基金项目9项，其中主持国家自然科学基金2项，中国博士后基金特别资助1项，中国博士后面上项目1项，省部级及校级基金5项。指导大学生创新实验项目8项及开放性实验2项。已发表SCI论文50多篇，其中以第一或通讯作者发表SCI收录论文17篇，参与授权专利5项，参编教材专著5部。
担任西省实验动物学会理事、陕西省药理学会理事、中国病理生理学会蛋白质修饰与疾病专业委员会委员、中国药理学会生化与分子药理学专业委员会委员、中国药理学会抗炎免疫药理学专业委员会青年委员、陕西省药理学会生化与分子药理学专业委员会常务委员等，现任《中国动脉硬化杂志》和《中国临床药理学与治疗学》青年编委。
获得中国药理学会颁发的青年药理学工作者奖，获得2022年陕西省科技进步奖二等奖（第二完成人）, 参与获得中国实验动物学会科学技术奖二等奖（2018年）和三等奖（2020年），陕西省药理学会优秀论文一等奖（2018年）。
以第一/通讯作者发表SCI论文
1. He J, Deng Y, Ren L, Jin Z, Yang J, Yao F, Zheng Z, Liu Y, Wang B, Zhang Y, Nan G, Wang W* Lin R*. Isoliquiritigenin from licorice flavonoids attenuates NLRP3-mediated pyroptosis by SIRT6 in vascular endothelial cells. Journal of Ethnopharmacology. 2023, 303:115952.
2. Li G, Shang C, Li Q, Chen L, Yue Z, Ren L, Yang J, Zhang J, Wang W*. Combined Shikonin-Loaded MPEG-PCL Micelles Inhibits Effective Transition of Endothelial-to-Mesenchymal Cells. International Journal of Nanomedicine. 2022,17:4497-4508.
3. Chen L, Shang X, Wang B, Wang G, Jin Z, Yao F, Yue Z, Bai L, Wang R, Zhao S, Liu E, Wang W*. HDAC3 inhibitor suppresses endothelial-to-mesenchymal transition via modulating inflammatory response in atherosclerosis. Biochemical Pharmacology. 2021,192:114716.
4. Chen L, Wang G, He J, Yang X, Zheng Z, Deng Y, Liu Y, Chen D, Lin R, Wang W*. SIRT6 inhibits endothelial-to-mesenchymal transition through attenuating the vascular endothelial inflammatory response. International Immunopharmacology. 2021,101:108240.
5. Wang W, Chen L, Shang C, Jin Z, Yao F, Bai L, Wang R, Zhao S, Liu E. miR-145 inhibits the proliferation and migration of vascular smooth muscle cells by regulating autophagy. Journal of Cellular and Molecular Medicine, 2020,12:6658-6669.
6. Wang W, Shang C, Zhang W, Jin Z, Yao F, He Y, Wang B, Li Y, Zhang J, Lin R*. Hydroxytyrosol NO regulates oxidative stress and NO production through SIRT1 in diabetic mice and vascular endothelial cells. Phytomedicine, 2019,52:206-215.
7. Li Y, Yao F, Shang C, Ren F, Zhang J, Li Y, Yang G, Lin R, Wang W*. Preparation, characterization and in vivo evaluation of pharmacological activity of different crystal forms of ibuprofen. Pakistan Journal of Pharmaceutical Sciences, 2019,32:2139-2147.
8. Wang W, Chen Y, Bai L, Zhao S, Wang R, Liu B, Zhang Y, Fan L, Liu E. Transcriptomic analysis of the liver of cholesterol-fed rabbits reveals altered hepatic lipid metabolism and inflammatory response. Scientific Reports, 2018,8:6437.
9. Wang W, Jing T, Yang X, He Y, Wang B, Xiao Y, Shang C, Zhang J, Lin R. Hydroxytyrosol regulates the autophagy of vascular adventitial fibroblasts through SIRT1-mediated signaling pathway. Canadian Journal of Physiology and Pharmacology, 2018,96:88-96.
10. Wang W, Li T, Jing T, Li Y, Yang X, He Y, Zhang W, Zhang J, Lin R. SIRT1 regulates the inflammatory response of vascular adventitial fibroblasts through autophagy and related signaling pathway. Cellular Physiology and Biochemistry, 2017,41:569-582.
11. Wang W, Liu E, Zhang J, Li Y, Yang X, He Y, Zhang W, Jing T, Lin R. Activation of PPAR alpha by fenofibrate inhibits apoptosis in vascular adventitial fibroblasts partly through SIRT1-mediated deacetylation of FoxO1. Experimental Cell Research, 2015,338:54-63.
12. Wang W, Zhang J, Li Y, Yang X, He Y, Li T, Ren F, Zhang J, Lin R. Divalproex sodium enhances the anti-leukemic effects of imatinib in chronic myeloid leukemia cells partly through SIRT1. Cancer Letters, 2015,356:791-799.
13. Wang W, Bai L, Qiao H, Li Y, Yang L, Zhang J, Lin R, Ren F, Zhang J, Ji M. The protective effect of fenofibrate against TNF-α-induced CD40 expression through SIRT1-mediated deacetylation of NF-κB in endothelial cells. Inflammation, 2014, 37(1):177-185.
14. Wang W, Lin Q, Lin R, Zhang J, Ren F, Zhang J, Ji M, Li Y. PPARα agonist fenofibrate attenuates TNF-α-induced CD40 expression in 3T3-L1 adipocytes via the SIRT1-dependent signaling pathway. Experimental Cell Research, 2013, 319(10):1523-1533.
15. Wang W, Yan C, Zhang J, Lin R, Lin Q, Yang L, Ren F, Zhang J, Ji M, Li Y. SIRT1 inhibits TNF-α-induced apoptosis of vascular adventitial fibroblasts partly through the deacetylation of FoxO1. Apoptosis, 2013, 18(6):689-701.
16. Wang W, Lin R, Zhang J, Mao Y, Bu X, Ji Q, Zhai X, Lin Q, Zhang K. Involvement of fatty acid metabolism in the hepatotoxicity induced by divalproex sodium. Human & Experimental Toxicology, 2012, 31(11):1092-1101.
17. Wang W, Lin R, Zhang H, Lin Q, Yang L, Zhang K, Ren F. The effects of Buyang Huanwu Decoction on hemorheological disorders and energy metabolism in rats with coronary heart disease. Journal of Ethnopharmacology, 2011, 137(1): 214-220.
联系方式
Email: szb2013072@xjtu.edu.cn
联系电话：029-82655363
联系地址：西安市雁塔区雁塔西路76号西安交通大学医学部
个人主页：http://gr.xjtu.edu.cn/web/szb2013072
