基本信息

姓名：张伊

职称：教授、博士生导师

电子邮箱：zhangyixjtu@xjtu.edu.cn

招生方向

1.病理生理学：先天、遗传性疾病及心律失常发病机制及防治研究

2.生理学：心脑血管疾病与代谢性疾病的发病机制及防治研究

研究方向

心血管病理生理学：

1.鞘磷脂信号调控在心肌、血管内皮中介导心脏重构和纤维化的病理机制；

2.内质网-线粒体互作在钙稳态-氧化应激信号介导心律失常的病理机制。

教育及工作经历

2024.01~至今，西安交通大学医学部,基础医学院,生理学与病理生理学系，教授，博导

2017.11~2023.12，西安交通大学基础医学院生理学与病理生理学系，副教授，博导

2012.11~2017.10，美国康奈尔大学威尔医学院病理与实验药物学系，博士后

2007.09~2012.07，北京大学分子医学研究所，生物物理学，博士（导师：程和平院士）

2003.09~2007.07，中国农业大学，学士

业绩简介

本人研究方向主要围绕细胞内鞘磷脂信号和钙信号的病理生理调控过程及其对心血管系统的影响，主要的研究成果包括：

①从力生物学调控的全新角度，阐述了病理性机械牵张通过调控心肌细胞肌浆网钙泄漏，导致房颤、心衰等心脏疾病的致病机制（Cardiovasc Res，2021，IF:14.239，入选ESI高被引论文）。

②揭示了S1P/S1PR1通过调控内质网钙信号，激活K_Ca2.3/K_Ca3.1介导的内皮依赖性超极化，促进血管舒张的新机制（Arterioscler Thromb Vasc Biol，2023，IF:10.514，心血管领域知名教授Prof. Faraci撰写专文点评）。

③阐明了内皮Nogo-B通过抑制鞘磷脂合成，对内皮细胞及血管功能的调控作用，及其对高血压、压力超负荷心衰等疾病进程的影响（Nat Med，2015；JCI insight，2016）。

④揭示了内皮Nogo-B通过稳定Mfn2加强线粒体相关内质网膜结构，从而促进线粒体Ca²⁺摄取和氧化应激水平，介导冠状动脉粥样硬化发生发展的病理过程（Redox Biol，2023，IF: 11.4）。

⑤阐明心脏微血管内皮S1P/S1PR1激活NFATc2信号上调MYPT1表达，并通过抑制TRPV4介导的钙内流，降低MYPT1磷酸化及细胞骨架收缩，对心脏微血管内皮屏障功能发挥重要保护作用（Hypertension，2025，IF:8.2）。

目前共发表研究性论文30余篇，其中通讯/第一作者研究性论文14篇（6篇IF>10），主持国家自然科学基金面上项目2项、航天医学实验项目1项、中国博士后基金项目2项、陕西省自科项目2项。2019年入选西安交通大学医学部“攀登人才”计划。现任中国病理生理学会理事，病理生理学会心血管专业委员会青年委员。

代表性SCI论文

1.Xin-Yi Zhao, Rui Xu, Jing-Jing Li, Yu-Peng Chen, Pei-Ning Liu, Jia-Hui Yao, Xin-Pei Wang, Yi-Wei Hu, Jing Lou, Fan Xu, Gang She, Zheng-Da Pang, Ning Huang, Zhe Song, Xiu-Ling Deng, Xiao-Jun Du, Xing Zhang*,Yi Zhang*(第一通讯作者), Wenjun Xie*.S1PR1-MYPT1 Maintains Coronary Endothelial Barrier in Pressure-Overloaded Hearts.Hypertension.2025 (In press).(IF:8.2)

2.Gang She, Xia-Xia Hai, Li-Ye Jia, Yong-Jian Zhang, Yu-Jie Ren, Zheng-Da Pang,Lin-Hong Wu, Meng-Zhuan Han, Yu Zhang, Jing-Jing Li, Ru-Yue Bai, Bao-Chang Lai,Yi-Yi Yang, Junichi Sadoshima, Xiao-Jun Du* , Xiu-Ling Deng*,Yi Zhang*(共同通讯作者).Hippo pathway activation mediates cardiomyocyte ferroptosis to promotedilated cardiomyopathy through downregulating NFS1.Redox Biology.82 (2025) 103597 (IF:11.9)

3.Yu Zhang, Jing-Jing Li, Rui Xu, Xin-Pei Wang, Xin-Yi Zhao, Yuan Fang, Yu-Peng Chen, Shan Ma, Xiao-Hui Di, Wei Wu, Gang She, Zheng-Da Pang, Yi-Dong Wang, Xing Zhang, Wenjun Xie, Xiu-Ling Deng, Xiao-Jun Du,Yi Zhang*. Nogo-B mediates endothelial oxidative stress and inflammation to promote coronary atherosclerosis in pressure-overloaded mouse hearts.Redox Biology.2023 Dec; 68:102944.(IF=11.4)

4.Jing-Jing Li^#, Xin-Yi Zhao^#, Yan Wang^#, Rui Xu, Xiao-Hui Di, Yu Zhang, Hongyan Yang, Meng-Zhuan Han, Ru-Yue Bai, Lin Xie, Zheng-Da Pang, Xing Zhang, Jianbao Zhang, Xiao-Jun Du, Xiu-Ling Deng*,Yi Zhang* (corresponding author), Wenjun Xie*. Endothelial KCa3.1 and KCa2.3 Mediate S1P (Sphingosine-1-Phosphate)-Dependent Vasodilation and Blood Pressure Homeostasis.Arterioscler Thromb Vasc Biol. 2023 May; 43(5):726-738. (IF=10.514，Commented by Prof. Faraci inArterioscler Thromb Vasc Biol. 2023 Jun;43(6):852-854)

5.Linda Sasset^#, Onorina Laura Manzo^#,Yi Zhang^#(co-first author), Alice Marino, Luisa Rubinelli, Maria Antonietta Riemma, Madhavi Latha S Chalasani, Dragos C Dasoveanu, Fiorentina Roviezzo, Stanislovas S Jankauskas, Gaetano Santulli, Maria Rosaria Bucci, Theresa T Lu, Annarita Di Lonrenzo*. Nogo-A reduces ceramide de novo biosunthesis to protect from geart failure.Cardiovasc Res. 2023 Mar 31; 119(2):506-519. (IF=14.239)

6.Ying Qi^#, Jing-Jing Li^#, Xiao-Hui Di^#, Yu Zhang^#, Jie-Long Chen, Zi-Xuan Wu, Zi-Yue Man, Ru-Yue Bai, Fujian Lu, Jie Tong, Xue-Liang Liu, Xiu-Ling Deng, Jianbao Zhang, Xing Zhang,Yi Zhang*(corresponding author), and Wenjun Xie*. Excess sarcoplasmic reticulum-mitochondria calcium transport induced by Sphingosine-1-phosphate contributes to cardiomyocyte hypertrophy.Biochim Biophys Acta Mol Cell Res.2021 Apr; 1868(5):118970. (IF=5.011)

7.Yi Zhang^#, Ying Qi^#, Jing-Jing Li^#, Xiao-Hang Gao, Yu Zhang, Xia Sun, Wen-Jin He, Jie Tong, Jianbao Zhang, Xiu-Ling Deng, Xiao-Jun Du, Wenjun Xie*. Stretch-induced sarcoplasmic reticulum calcium leak is causatively associated with atrial fibrillation in pressure-overloaded hearts.Cardiovasc Res.2021 Mar 21;117(4):1091-1102. (IF=14.239)

8.Yi Zhang^#, Meng-Chen Hou^#, Jing-Jing Li, Ying Qi, Yu Zhang, Gang She, Yu-Jie Ren, Wei Wu, Zheng-Da Pang, Wenjun Xie, Xiu-Ling Deng*, Xiao-Jun Du*. Cardiac β-adrenoceptor activation mediates diverse and cell type-dependent changes in the expression and distribution of connexin 43.J Cell Mol Med.2020 Aug; 24(15):8505-8517. (IF=5.310)

9.LindaSasset^#,YiZhang^#(co-first author),TeresaM. Dunn, and AnnaritaDi Lorenzo*. Sphingolipid De NovoBiosynthesis:A Rheostat ofCardiovascular Homeostasis.TrendsEndocrinolMetab.2016 Nov; 27(11):807-819. (IF=10.983)

10.YiZhang,YanHuang, AnnaCantalupo,PaulaS. Azevedo, Mauro Siragusa,Jacek Bielawski, Frank J. Giordano,and AnnaritaDi Lorenzo*. Endothelial Nogo-B regulates sphingolipid biosynthesis to promote pathological cardiac hypertrophy during chronic pressure overload.JCIInsight.2016 Apr 21; 1(5): e85484. (IF=6.014)

11.AnnaCantalupo^#,YiZhang^#(co-first author), Milankumar Kothiya, SylvainGalvani, HideruObinata,MariarosariaBucci, Frank J. Giordano,Xian-Cheng Jiang,Timothy Hla, and AnnaritaDi Lorenzo*.Nogo-B regulates endothelial sphingolipidhomeostasisto control vascular function andbloodpressure.NatMed.2015Sep; 21(9):1028-37. (IF=30.641)

12.XianhuaWang*^#,Wenjun Xie^#,YiZhang^#(co-firstauthor), Peihui Lin,Liang Han, Peidong Han,YanruWang,Zheng Chen, GuangjuJi,Ming Zheng,NoahWeisleder,Rui-Ping Xiao, HiroshiTakeshima,Jianjie Ma*, andHeping Cheng. Cardioprotectionofischemia-reperfusioninjury bycholesterol-dependentMG53-mediated membranerepair.CircRes.2010Jul 9; 107(1):76-83. (IF=15.862)