吕海侠
研究领域或方向
1）神经干细胞基础和应用研究；
2）神经损伤修复与神经功能康复；
3）神经组织工程；
工作简历
1990.07-2008.05 西安交通大学医学院第二附属医院妇产科 医师
2008.05-2008.07 西安交通大学医学院神经生物学研究所 讲师
2008.08-2013.12 西安交通大学医学院神经生物学研究所 副教授
2014.1至今 西安交通大学医学院神经生物学系 教授
科研项目
（1）自愿运动改善niche信号调控内源性NSCs行为促进脑损伤修复的作用及机制（国家自然科学基金面上项目，82171389）2022.1-2026.12，55万元
（2）瘦素调节NSCs/NPCs分化平衡促进脑损伤后神经再生修复的作用及机制研究（国家自然科学基金面上项目，81870981）2019.1-2022.12，61万元
（3）Lep-Rb介导信号通路参与脑损伤后神经再生修复的作用及机制（国家自然科学基金面上项目，81571205）2016.1-2019.12，57万元
（4）利用SOCS3抑制大鼠脑缺血后反应性星形胶质细胞增生促进神经损伤修复的作用及机理研究（国家自然科学基金面上项目，31271151）2013.1-2016.12，90万元
（5）表达SOCS3工程化神经干细胞抑制大鼠脑缺血后反应性星形胶质细胞增生促进神经损伤修复的作用及机理研究（神经科学国家重点实验室开放项目） 28.0万元
（6）缺血缺氧脑损伤后神经营养素3诱导神经再生的miRNA机制研究（国家自然科学基金面上项目，31070943）2011.1-2013.12，33万
（7）3-羟基丁酸作为脑组织工程生物活性材料的机制研究（2014年西安交通大学交叉学科项目）10.0万元
（8）脑组织工程研究（2009年及2010年西安交通大学交叉学科项目2项）21.0万元
学术科研
陕西省青年科技奖及王宽诚育才奖获得者；中国神经科学学会理事、中国解剖学会神经解剖学分会委员，陕西省解剖学会副理事长。围绕神经干细胞与脑损伤修复开展研究，主持科研项目15项，其中国家自然科学基金面上项目5项；获陕西省科技三等奖1项，陕西省高等学校科学技术一等奖1项；发表科技论文104篇，其中SCI收录论文56篇；参加国际国内学术会议30余次，会议发言10次，培养硕/博士研究生21名，博士后3名。
近5年发表科研论文列表：
(1) An Jing, Tan Ruolan, Hu Xiaoxuan, Cai Zhenlu, Sun Meiqi, Ge Qian, Ma Wen, Li Huiliang, Lu Haixia*. Kinase inhibit region of SOCS3 attenuates IL6 induced proliferation and astrocytic differentiation of neural stem cells via crosstalk between signaling pathways. CNS Neurosci Ther. 2022, First published: 10 October 2022 https://doi.org/10.1111/cns.13992
(2) Hu Xiaoxuan†, An Jing †, Ge Qian†, Sun Meiqi, Zhang Zixuan, Cai Zhenlu, Tan Ruolan, Ma Tianyou* and Lu Haixia*. Maternal High-Fat Diet Reduces Type-2 Neural Stem Cells and Promotes Premature Neuronal Differentiation during Early Postnatal Development. Nutrients. 2022, 14(14): 2813. doi: 10.3390/nu14142813
(3) )Ge Qian, Hu Xiaoxuan, Ma Ning, Sun Meiqi, Zhang Liyun, Cai Zhenlu, Tan Ruolan, Lu Haixia*. Maternal high-salt diet during pregnancy impairs synaptic plasticity and memory in the offspring. The FASEB Journal. 2021,35(4):e21244. doi: 10.1096/fj.202001890R
(4) Cai Zhenlu, Hu Xiaoxuan, Tan Ruolan, Feng Yunran, Sun Miqi, Ma Ning, Li Xingxing, Huang Li, Anjing, Ge Qian*, Lu Haixia*. Neuroprotective effect of green tea extractives against oxidative stress by ehancing the survival and proliferation of PC12 cells. Mol Cell Toxicol. 2019, 15,391-397
(5) Lu pengfei, Han Donghe, Zhu Kunming, Jin Meihua, Mei Xifan, Lu Haixia*. Effects of SIRT1 on microglia in spinal cord injury: Involvement of Wnt/β-catenin signaling pathway. Neuroreport. 2019, 30(13):867–874
(6) Wang Leilei, Yang Zhiqian, Fang Fan, Sun Shuhong, Wu Xingjuan, Lu Haixia*, Lu Xiaoyun*. PHBHHx facilitated the residence, survival and sternness maintain of transplanted neural stem cells in traumatic brain injury rats. Biomacromolecules. 2019, 20(9): 3294-3302. doi: 10.1021/acs.biomac.9b00408.
(7) Wu Gang, Zhao Xixi, Wang Feidi, Tan Ruolan, Wang Jin, Li Xingxing, Chen Chen, Cai Zhenlu, An Jing, Lu Haixia*. Short-term exposure to oxycodone altering survival, proliferation and differentiation of rat embryonic neural stem cell in vitro. Brain Res Bull. 2018, 143, 66-72
(8) Li Xingxing, Tan Ruolan, Hu Xiaoxuan, Jiao Qian, Md Saidur Rahman, Chen Xinlin, Zhang Pengbo, An Jing*, Lu Haixia*, Liu Yong. Neural stem cells derived factors inhibit the growth and invasion of U87 stem-like cells in vitro. J Cell Biochem. 2018, 1-8, https://doi.org/10.1002/jcb.27826
(9) Shang Sen, Wang Leilei, Zhang Yali, Lu Haixia*, Lu Xiaoyun*. The Beta-Hydroxybutyrate Suppresses the Migration of Glioma Cells by Inhibition of NLRP3 Inflammasome. Cell Mol Neurobiol. 2018, 38(8):1479-1489 doi: 10.1007/s10571-018-0617-2.
(10) Lu Na, Li Xingxing, Tan Ruolan, An Jing, Cai Zhenlu, Hu Xiaoxuan, Wang Feidi, Wang Haoruo, Lu Chengbiao, Lu Haixia*. HIF-1α/Beclin1-mediated autophagy is involved in neuroprotection induced by hypoxic preconditioning. J Mol Neurosci. 2018, 66(2):238-250. DOI: 10.1007/s12031-018-1162-7
(11) Hu Erling, Du Huan, Zhu Xinliang, Wang Leilei, Shan Sen, Wu Xinjuan, Lu haixia*, Lu Xiaoyun*. Beta-hydroxybutyrate promotes the expression of BDNF in hippocampal neurons under adequate glucose supply. Neuroscience. 2018, 386:315-325. DOI:10.1016/j. neuroscience. 2018.06.036
(12) Huang Li, Zhang Che, Gu Jiaowei, Wu Wei, Shen Zhujun, Zhou Xihui, Lu Haixia*. A randomized, placebo-controlled trial of human umbilical cord blood mesenchymal stem cell infusion for children with cerebral palsy. Cell Transplantation. 2018, 27(2):325-334. DOI: 10.1177/0963689717729379
(13 )An Jing#, Yan Hanqi#, Li Xingxing, Tan Ruolan, Chen Xinlin, Zhang Zhichao, Liu Yingfei, Tan Jing, Zhang Pengbo, Lu Haixia*, Liu Yong. The inhibiting effect of neural stem cells on proliferation and invasion of glioma cells. Oncotarget. 2017, 8(44):76949-76960. doi: 10.18632/oncotarget.
(14) Jiao Qian, Li Xingxing, An Jing, Zhang Zhichao, Chen Xinlin, Tan Jing, Zhang Pengbo, Lu Haixia*, Liu Yong*. Cell-cell connection enhances proliferation and neuronal differentiation of rat embryonic neural stem/progenitor cells. Front Cell Neurosci. 2017, 11: 200. doi: 10.3389/fncel.2017.00200.
(13）王昊若，葛茜，吕海侠*. 创伤后应激障碍的记忆损害相关结构研究进展. 国际精神病学杂志. 2020,47(01):18-20.
(14) 申艺玮，薛心雨，吕海侠*. 丙泊酚对长时程增强的影响及机制研究进展. 国际麻醉与复苏杂志. 2020,41(7): 692-695
(15)王煜，吴刚，吕海侠*，王菲迪. 光生物调节保护老年患者术后认知功能的研究进展. 国际麻醉学与复苏杂志, 2019(12): 1172-1177
(16)史会明, 王飞, 胡远军, 吕海侠*, 王盛海, 陈亮, 申雪莹. 基于3D模型并肩胛骨接骨板设计的肩胛骨测量. 中国临床解剖学杂志. 2018, 36 (4): 387-391
（17）)陈晨, 刘冠志, 吕海侠*. 药物成瘾引发欺骗行为的神经生物学基础. 中国药物依赖性杂志. 2018.27(3), 171-175
（18）王菲迪, 安晶, 吴刚, 吕海侠*. 羟考酮在特殊人群中的临床应用研究进展. 国际麻醉学与复苏杂志. 2017, 38(10):930-933, 952.
（19）吴兴娟, 卢晓云, 王蕾蕾, 丁岩, 吕海侠*. 3-HB协同bFGF诱导促进神经干细胞向神经元方向分化. 西安交通大学学部医学版. 2017,38(5):633-638
联系方式
联系电话：029-82657064
Email:hxl01@mail.xjtu.edu.cn
个人主页：hxl01.gr.xjtu.edu.cn
Haixia Lu, Professor in department of Neurobiology, Xi’an Jiaotong University Health Science Centre. During Sep 2009 to Feb 2010 and Jul 2006 to Jan 2008, worked in School of Biomedical Science, Queen’s Medical Center, University of Nottingham, UK, as research fellow and postdoctoral fellow.
Research interests:
1. Biological behaviour and the therapeutic application of neural stem cell (endogenous and exogenous)
2. Neural regeneration ( neurogenesis and angiogenesis), Neural inflammation, Neural plasiticity and rehabilitation
3. Stem cell tissue engineer
Education：Jul 1997, got Master degree in Obstetrics & Gynecology and in Dec 2002, got PhD in Human Anatomy & Histoembryology, in Xi’an Jiaotong University.
Honor & Awards：2020, Wang KC Yucai Award; 2014, The Tenth Youth Science and Technology Award of Shaanxi Province; 2008, Award from Symington Request Fund for travel to UK for ASGBI meeting.
Grant Support : Based on the research on neural stem cells and neural regeneration, presided over 14 scientific research projects, including 5 grants from the National Natural Science Foundation of China
Publication: Totally 104 scientific papers had been pubilished, including 56 papers in SCI journals. Attended more than 30 international and domestic academic conferences, performed 10 conference speeches.
