陈莉娜

陈莉娜 教授 博士生导师

研究领域（方向）

内分泌药理学和心血管药理学

个人及工作简历

陈莉娜，教授，博士生导师，基础医学院党委副书记，本科生院基础医学系副主任。研究方向为内分泌药理学和心血管药理学，主要从事糖尿病等代谢性疾病的发病机制及药物防治研究。2009-2010年在美国内布拉斯加大学医学中心药理学与实验神经科学系做访问学者；2015年8-11月赴美学习医学教育教学法。先后主持国家自然科学基金2项、国家重大新药创制专项1项、省科技统筹项目1项，参与多项国家级和省部级课题；发表文章60余篇，其中SCI收录24篇；申报国家发明专利2项；获陕西省科技进步二等奖1项（第三完成人）；担任10多种国外杂志审稿人。承担医药学各专业本科生双语教学，留学生英语教学及硕士生专业课；主持和参与教改项目多项；获校级教学成果二等奖1项（第二完成人）；参编规划教材10余部。担任中国药理学会定量药理学专业委员会委员、中国药理学会药理学教学与科普专业委员会委员、中华医学会医学教育分会青年委员会委员、陕西省药理学会常务委员、陕西省生理科学会委员等。

受教育经历：

2015/0816 – 2015/1116，美国内布拉斯加大学医学中心，访问学者

2001/09 – 2006/12，西安交通大学，医学院药理学系，医学博士

1992/09 – 1997/07，西安医科大学，预防医学系，医学学士

研究工作经历：

2018/01 –今， 西安交通大学，医学院药理学系，教授

2013/01 –2017/12，西安交通大学，医学院药理学系，副教授

2009/01 – 2010/01，美国内布拉斯加大学医学中心，药理学与实验神经科学系，访问学者

2006/12 – 2012/12，西安交通大学，医学院药理学系，讲师

科研项目

学术及科研成果、专利、论文

1. Cheng J, Zhang M, Cheng S, Li F, Zhang B, Sun X, Hu H,Chen L, Zhao Z, Hu H, Zhang Z. Low-dose alcohol ameliorated high fat diet-induced anxiety-related behavior via enhancing adiponectin expression and activating the Nrf2 pathway. Food Funct. 2020 Dec 9. Online ahead of print. PMID: 33295905

2. Cheng J, Li F, Sun X, Liu S,Chen L, Tian F, Zhao Z, Hu H, Li X. Low-dose alcohol ameliorated homocysteine-induced anxiety-related behavior via attenuating oxidative stress in mice. Neurosci Lett. 2020, 714:134568.

3. Wei-Jiang Dong, Wen-Bin Liu,1Hui-Lin Gong, Yan-Bin Cheng, Ming Zhang, Yi Lyu, Xiao-Jian Wu, Xiao-Jun Meng, She-Min Lyu,Li-Na Chen,Qian Guo, Jin-Song Zhou, and Hong Yan*. A conceived model of “physician scientist” cultivation: exploring the double degrees of MD-PhD program. Chin Med J (Engl). 2020, 133(13): 1620–1622.

4. Yan W, Zhang M, Yu Y, Yi X, Guo T, Hu H, Sun Q, Chen M, Xiong H*,Chen L*. Blockade of voltage-gated potassium channels ameliorates diabetes-associated cognitive dysfunction in vivo and in vitro. Exp Neurol. 2019, 320:112988.

5. Yan W, Pang M, Yu Y, Gou X, Si P, Zhawatibai A, Zhang Y, Zhang M, Guo T, Yi X,Chen L*. The neuroprotection of liraglutide on diabetic cognitive deficits is associated with improved hippocampal synapses and inhibited neuronal apoptosis. Life Sci. 2019, 231:116566.

6. Sun PF, Tian T,Chen LN, Fu RG, Xu SS, Ai H, Wang B, Zhang J, Si RY, Chai Z, Cooper ME, Ren ST*. Ultrasound Combined with Microbubbles Enhances the Effects of Methylprednisolone in Lipopolysaccharide-Induced Human Mesangial Cells. J Pharmacol Exp Ther. 2018, 365(3):476-484.

7. Liu S*, Hou X,Chen L, Hu H, Sun Q, Zhao F, Liu C. Enhancing amplification of late-outgrowth endothelial cells by bilobalide. J Cell Mol Med. 2018, 22(7):3340-3352.

8. Lan ZM, Wang LP, Chong ZY, Yang GD, Yu XJ,Chen L*, Zhou J*. Evaluation of the acute and chronic toxicity of the jiangu capsules. Experimental and Therapeutic Medicine, 2017, 14:6229-6237.

9. Wang M, Yan W, Liu Y, Hu H, Sun Q, Chen X, Zang W,Chen L*. Erythropoietin ameliorates diabetes-associated cognitive dysfunction in vitro and in vivo. Sci Rep, 2017, 7(1):2801.

10. Ji W, Zhao M, Wang M, Yan W, Chen M, Liu Y, Ren S, Lu J, Wang B,Chen L*. Effects of canagliflozin on weight loss in high-fat diet-induced obese mice. PLoS One, 2017, 12(6):e0179960.

11. Lu Y, Zhao M, Liu JJ, He X, Yu XJ, Liu LZ, Sun L,Chen LN*, Zang WJ^*.Long-term administration of pyridostigmine attenuates pressure overload-induced cardiac hypertrophy by inhibiting calcineurin. J Cell Mol Med, 2017, 21(9):2106-2116.

12. Yang B, Li C, Sun J, Wang X, Liu X, Yang C,Chen L, Zhou J, Hu H^*.Inhibition of potassium currents is involved in antiarrhythmic effect of moderate ethanol on atrial fibrillation. Toxicol Appl Pharmacol, 2017, 322:89-96.

13. Lu J#, Ji W#, Zhao M#, Wang M, Yan W, Chen M, Ren S, Yuan B, Wang B,Chen L*. Protamine zinc insulin combined with sodium selenite improves glycometabolism in the diabetic KKAy mice. Sci Rep, 2016, 6:26563.

14. Liu L, Liu C, Hou L, Lv J, Wu F, Yang X, Ren S, Ji W, Wang M,Chen L*. Protection against ischemia/reperfusion induced renal injury by co-treatment with erythropoietin and sodium selenite. Mol Med Rep, 2015, 12(6): 7933-7940.

15. Chen LN, Sun Q, Liu SQ, Hu H, Lv J, Ji WJ, Wang M, Chen MX, Zhou J*. Erythropoietin improves glucose metabolism and pancreatic β-cell damage in experimental diabetic rats. Mol Med Rep, 2015, 12(4):5391-5398.

16. Ji W#, Chen X#, Lv J, Wang M, Ren S, Yuan B, Wang B,Chen L*. Liraglutide Exerts Antidiabetic Effect via PTP1B and PI3K/Akt2 Signaling Pathway in Skeletal Muscle of KKAy Mice. Int J Endocrinol. 2014, 2014:312452.

17. Yang XF, He Y, Li HY, Liu X, Chen H, Liu JB, Ji WJ, Wang B,Chen LN*. Hepatoprotective effects of erythropoietin on D-galactosamine/lipopolysaccharide-induced fulminant hepatic failure in mice. Mol Med Rep, 2014, 10(1):555-559.

18. Chen LN, Lyu J, Yang XF, Ji WJ, Yuan BX, Chen MX, Ma X, Wang B*. Liraglutide ameliorates glycometabolism and insulin resistance via GLUT4 up-regulation in diabetic KKAy mice. Int J Mol Med, 2013, 32(4):892-900.

联系方式

地址：西安市雁塔西路76号西安交通大学医学部科教楼九层

邮箱：chenlin@xjtu.edu.cn

电话：18220554189