个人简介：高丹副教授，硕/博士生导师。
研究方向：脂肪组织与肥胖及相关代谢疾病
教育背景
·2006.1-2009.7英国阿斯顿大学生命科学与健康学院博士
·2004.9-2005.9英国阿伯丁大学人类营养与代谢硕士
·1999.9-2004.7中国医科大学医学学士
工作经历
·2021.7-西安交通大学创新港转化医学研究院分子转化医学研究所
炎症生物学团队Co-PI
·2017.7- 西安交通大学医学部基础医学院人体解剖与组织胚胎系副教授
·2017.1-2017.6 西安交通大学生命科学与技术学院副教授
·2014.10-2016.10西安交通大学前沿科学技术研究院线粒体生物
医学中心PI小组主任3类
·2012.7–2014.9 美国加州City of Hope Beckman研究所糖尿病与代谢疾病系
博士后
·2009.4–2012.4 英国利物浦大学医学院衰老和慢性研究所肥胖与内分泌系
博士后
科研项目
1.陕西省自然科学基金一般项目（面上）2024.1-2025.12主持
2.国家自然基金面上项目，2019.01-2022.12，主持，已结题
3．国家自然科学青年项目，2017.01-2019.12，主持，已结题
4．第11批中国博士后基金特别资助, 2018.1-2019.12,主持，已结题
5．第61批中国博士后科学基金二等资助, 2017.1-2019.12,主持，已结题
6．陕西省博士后基金（一等资助），2018.01-2019.12,主持，已结题
7．陕西省自然科学青年基金，2016.01-2017.12，主持，已结题
8.西安交通大学基本科研业务费（国际前沿与自由创新类项目）(xjj2015049)2015.1-2017.12 主持，已结题
代表性论文（第一作者或通讯作者文章）
1.Chang K, Lin L, Cui T, Zhao H, Li J, Liu C,Gao D*,Lu S*.Zinc-a2-Glycoprotein Acts as a Component of PNN to Protect Hippocampal Neurons from Apoptosis.Mol Neurobiol.2023Nov 25. doi: 10.1007/s12035-023-03771-4.(* co-corresponding author)(5-year：5.1)
2.Li X, Ren Y, Chang K, Wu W, Griffiths HR, Lu S,Gao D.Adipose tissue macrophages as potential targets for obesity and metabolic diseases.Front Immunol.2023Apr 19;14:1153915. doi: 10.3389/fimmu.2023.1153915. eCollection2023. (5-year：8.0)
3.Ren Y, Zhao H, Yin C, Lan X, Wu L, Du X,Griffiths HR,Gao D*.Adipokines, Hepatokines and Myokines: Focus on Their Role and Molecular Mechanisms in Adipose Tissue Inflammation.Front Endocrinol(Lausanne).2022Jul 14;13:873699. doi: 10.3389/fendo.2022.873699. eCollection2022. (5-year：5.9)
4.Gao D, Hu S, Zheng X, Lin W, Gao J, Chang K, Zhao D, Wang X, Zhou J, Lu S,Griffiths HR,Liu J.SOD3 is secreted by adipocytes and mitigates high-fat diet-induced obesity, inflammation, and insulin resistance.Antioxid Redox Signal.2020Jan 20;32(3):193-212.(5-year: 8.2)
5.Wang X#, Zhao D#, Cui Y, Lu S,Gao D*,Liu J*.Pro-inflammatory macrophages impair skeletal muscle differentiation in obesity through secretion of TNFα via sustained activation of p38 MAPK.J Cell Physiol.2019Mar;234(3):2566-2580.(*co-corresponding author)(5-year：5.9)
6.Lin W, Liu Z; Zheng X,Gao D*, Tian Z* High-salt diet affects amino acid metabolism in plasma and muscle of Dahl salt-sensitive rats. Amino acids. 2018 Oct;50(10):1407-1414.(* co-corresponding author)(5-year IF：3.5)
7.Jin L*,Gao D*, Feng T, Tremblay JR, Ghazalli N, Luo A, Rawson J, Quijano JC, Chai J, Wedeken L, Hsu J, LeBon J, Walker S, Shih HP, Mahdavi A, Tirrell DA, Riggs AD, Ku HTCells with surface expression of CD133highCD71low are enriched for tripotent colony-forming progenitor cells in the adult murine pancreas.Stem Cell Res.2016Jan;16(1):40-53. (* co-first author) (IF：3.929)
8.Gao D,Madi M, Ding C, Fok M, Steele T, Ford C, Hunter L, Bing C.Interleukin-1β mediates macrophage-induced impairment of insulin signaling in human primary adipocytes.Am J Physiol Endocrinol Metab.2014Aug ;307(3):E289-304(IF：3.825，5-year IF：4.66)
9.Gao D, Trayhurn P, Bing C.1,25-Dihydroxyvitamin D3 inhibits the cytokine-induced secretion of MCP-1 and reduces monocyte recruitment by human preadipocytes.Int J Obes (Lond).2013Mar;37(3):357-65.(IF：5.337)
10.Gao D,Pararasa C, Dunston CR, Bailey CJ,Griffiths HR.Palmitate promotes monocyte atherogenicity via de novo ceramide synthesis.Free Radic Biol Med.2012Aug 15;53(4):796-806(IF：5.784，5-year IF：5.982)
11.Gao D, Bing C.Macrophage-induced expression and release of matrix metalloproteinase 1 and 3 by human preadipocytes is mediated by IL-1β via activation of MAPK signaling.J Cell Physiol.2011Nov;226(11):2869-80.(IF: 4.155)
12.Gao D,Trayhurn P, Bing C.Macrophage-secreted factors inhibit ZAG expression and secretion by human adipocytes.Mol Cell Endocrinol.2010Aug 30;325(1-2):135-42.(IF：3.859, 5-year IF: 3.974)
13.Mracek T*,Gao D*, Tzanavari T, Bao Y, Xiao X, Stocker C, Trayhurn P, Bing C.
Downregulation of zinc-{alpha}2-glycoprotein in adipose tissue and liver of obese ob/ob mice and by tumour necrosis factor-alpha in adipocytes.JEndocrinol.2010Feb;204(2):165-72. (*co-first author)(IF：4.498)
14.Gao D,Griffiths HR, Bailey CJ.Oleate protects against palmitate-induced insulin resistance in L6 myotubes.Br J Nutr.2009Dec;102(11):1557-63.(IF: 3.311)
15.Gao D,Bailey CJ,Griffiths HR.Metabolic memory effect of the saturated fatty acid, palmitate, in monocytes.Biochem Biophys Res Commun.2009Oct 16;388(2):278-82(IF: 2.371)
联系方式
电子邮箱：dangao@xjtu.edu.cn
联系电话：187 9244 4132
联系地址：西安市雁塔西路76号西安交通大学医学部
