侯玉柱教授博士研究生导师
研究领域（方向）
主要从事肿瘤免疫学研究，从分子、细胞及机体整体水平上，研究肿瘤发生、发展及治疗过程中的免疫学机制，包括：（1）研究肿瘤发生、发展过程中的免疫监视与免疫逃逸；（2）研究放疗与免疫治疗过程中肿瘤免疫微环境以及系统性免疫反应。
工作经历
2011年9月－2014年12月：博士后，免疫学，中科院动物所；
2015年1月－2017年12月：博士后，肿瘤免疫学，美国芝加哥大学；
2018年1月－2019年12月：讲师，肿瘤免疫学，美国芝加哥大学；
2020年1月－至今：教授、博导，西安交通大学。
科研项目
主持国家自然基金面上项目、陕西省杰出青年项目、西安交大学青年拔尖人才（A类）项目等科研项目。
学术及科研成果、专利、论文
主要研究成果以第一或通讯作者发表在Immunity、Science Translational Medicine、Science Immunology、Journal of Hematology and Oncology、Nature Communications、Cancer Research、Clinical Cancer Research等国际著名学术期刊。合计公开发表SCI学术论文30余篇，被引用2700余次。
代表性论文
1.Yutiantian Lei, Rui Ji, Chen Chen, Peihai Cao, Jiahong Shi, Mengdi Huang, Qiuyu Mu, Yixin Wang, Dairu Hou, Mingjun Si, Ruishan Guo, Jiahao Sun, Dingge Jiang, Yihan Wang, Tingting Lv, Ruiying Wang, Junyi Zhang, Liuyi Yang, Renyi Ding, Wenhua Li, Haiyan Liu, Anjun Jiao, Linyun Hui, Chen Lin, Jinlu Ma*, Suxia Han*,Yuzhu Hou*. CXCR5+monocyte emigration impairs the radiation-induced antitumor immune response.Nature Communications, 2026; Published online.(IF: 15.7)
2.Shirong Zhang, Mengjie Liu, Deli Tan, Kejia Lv, Wenyuan Li, Xubo Huang, Jia Hou, Yaru Yang, Chen Chen, Jinteng Feng, Wenjuan Wang, Lili Jiang, Min Jiao, Zhiping Ruan, Ying Zan,Yuzhu Hou*, Hui Guo*. p57 increases immunotherapy efficacy by promoting cGAS-STING-mediated innate sensing in hepatocellular carcinoma.Cell Reports, 2026 Jan; 45(1):116769.(IF: 6.9)
3.Yufei Cao, Moujiang Zheng, Qinghao Zhou, Yansong Dong,Yuzhu Hou*, Zhishen Ge*. PolyMOF Radiosensitizers as Nanocarriers with X-Ray-Triggered Dual-Gas Release for Enhanced Radiotherapy.ACS Applied Materials & Interfaces, 2025, 17, 31, 44263–44274.(IF: 8.2)
4.Yufei Cao, Moujiang Zheng, Jiahong Shi, Jiale Si, Guopu Huang, Yuanyuan Ji,Yuzhu Hou*, Zhishen Ge*. X-ray-Triggered Activation of Polyprodrugs for Synergistic Radiochemotherapy.Biomacromolecules,2025 Jan 13;26(1):579-590.(IF: 5.5)
5.Jun-Rui Feng, Xue Li, Cong Han, Yue Chang, Yu Fu, Gong-Chang Feng, Yutiantian Lei, Hai-Yun Li, Patrick Ming-Kuen Tang, Shang-Rong Ji,Yuzhu Hou*, Yi Wu*. C-Reactive Protein Induces Immunosuppression by Activating FcγR2B in Pulmonary Macrophages to Promote Lung Metastasis.Cancer Research, 2024 Dec 16;84(24):4184-4198.(IF: 12.5)
6.Ke-Jia Lv, Si-Zhe Yu, Yu Wang, Shi-Rong Zhang, Wen-Yuan Li, Jia Hou, De-Li Tan, Hui Guo,Yuzhu Hou*.Cancer-associated fibroblasts promote the progression and chemoresistance of HCC by inducing IGF-1.Cellular Signalling, 2024 Dec:124:111378.(IF: 4.4)
7.Yuzhu Hou, Kaiting Yang, Liangliang Wang, Jiaai Wang, Xiaona Huang, András Piffkó, Sean Z Luo, Xinshuang Yu, Enyu Rao, Carlos Martinez, Jason Bugno, Matthias Mack, Everett E Vokes, Sean P Pitroda, Steven J Chmura, Ralph R Weichselbaum*, Hua Laura Liang*. Radiotherapy Enhances Metastasis Through Immune Suppression by inducing PD-L1 and MDSC in distal sites.Clinical Cancer Research, 2024; 30(9): 1945-1958(IF: 11.1)
8.Yuanyuan Zhang, Yujie Zhang, Yonghong Li, Yuhan Fu, Yuanru Zhao, Wei Zhao, Runqing Li, Yao Xian, Kangsheng Tu, Feng Wu, Cheng Li*,Yuzhu Hou*, Mingzhen Zhang*. Harnessing Ag2S quantum dots with immune adjuvant for NIR-II fluorescence imaging-guided sonodynamic immunotherapy of colon cancer.Chemical Engineering Journal,2023; 474(4):145685.(IF: 15.1)
9.Liangliang Xu#, Chang Zou#, Shanshan Zhang#, Timothy Shun Man Chu, YanZhang, Weiwei Chen, Caining Zhao, Li Yang, Zhiyuan Xu, Shaowei Dong, Hao Yu, Bo Li,Xinyuan Guan,Yuzhu Hou*, Feng-Ming Kong*. Reshaping the systemic tumor immuneenvironment (STIE) and tumor immune microenvironment (TIME) to enhance immunotherapy efficacyin solid tumors.Journal of Hematology and Oncology, 2022; 15(1):87.(IF:23.1)
10.Yuzhu Hou#*, Hua L Liang#, Xinshuang Yu, Zhida Liu, Xuezhi Cao, Enyu Rao,Xiaona Huang, Liangliang Wang, Lei Li, Jason Bugno, Yanbin Fu, Steven J Chmura, WenjunWu, Sean Z Luo, Wenxin Zheng, Ainhoa Arina, Jessica Jutzy, Anne R McCall, Everett EVokes, Sean P Pitroda, Yang-Xin Fu*, Ralph R Weichselbaum*. Radiotherapy andimmunotherapy converge on elimination of tumor-promoting erythroid progenitor cells throughadaptive immunity.Science Translational Medicine, 2021; 13(528):eabb0130.(IF:19.3)
11.Enyu Rao#,Yuzhu Hou#, Xiaona Huang, Liangliang Wang, Jiaai Wang, WenxinZheng, Hengjin Yang, Xinshuang Yu, Kaiting Yang, Jason Bugno, Xingchen Ding, EverettVokes, Yang-Xin Fu, Ralph R Weichselbaum*, Hua L Liang*. All-trans retinoic acid overcomessolid tumor radioresistance by inducing inflammatory macrophages.Science Immunology,2021; 6(60):eaba8426.(IF:30.6)
12.Yuzhu Hou, Hua Liang, Enyu Rao, Wenxin Zheng, Xiaona Huang, Liufu Deng,Yuan Zhang, Xinshuang Yu, Meng Xu, Helena Mauceri, Ainhoa Arina, Ralph RWeichselbaum*, Yang-Xin Fu*. Non-canonical NF-κB antagonizes STING sensor-mediated DNA sensingin radiotherapy.Immunity, 2018; 49(3): 490-503.(IF:22.5)
13.Yuzhu Hou#, Linnan Zhu#, Hongling Tian, Haixi Sun, Lianfeng Zhang, RuoyuWang, Yong Zhao*. IL-23-induced macrophage polarization and its pathological roles in micewithimiquimod-induced psoriasis.Protein Cell.2018 Dec; 9(12):1027-1038.(IF: 10.1)
14.Yuzhu Hou#, Haijiang Lin#, Linnan Zhu, Zhaoting Liu, Fanlei Hu, Jianfeng Shi,Tao Yang, Xiaoyun Shi, Huifang Guo, Lianfeng Zhang, Qiang Wang, Zhanguo Li, YongZhao*. The inhibitory effect of IFN-γ on protease HTRA1 expression in rheumatoid arthritis.Journal of Immunology, 2014; 193(1):130-8(IF:4.8)
15.Yuzhu Hou#, Haijiang Lin#, Linnan Zhu, Zhaoting Liu, Fanlei Hu, Jianfeng Shi,Tao Yang, Xiaoyun Shi, Mingzhao Zhu, Bernard F Godley, Qiang Wang, Zhanguo Li,Yong Zhao*. LPS increases the incidence of collagen-induced arthritis in mice through inductionof protease HTRA1 expression.Arthritis & Rheumatism. 2013; 65(11):2835-46.(IF:9.5)
联系方式
电子邮箱：houyuzhu@xjtu.edu.cn
联系地址：陕西省西安市雁塔西路76号
个人主页：https://gr.xjtu.edu.cn/en/web/0020200006
