个人简介：
张明真，西安交通大学基础医学院特聘研究员/博士生导师，西安交通大学一附院特聘教授，医学工程研究所副所长，目前主要从事组织器官损伤修复及干预策略研究。在包括Nat Commun, J Am Chem Soc, Bioactive Materials, Nano Today, Mol Ther, Anal Chem等权威刊物上发表论文80余篇，入选ESI高被引论文10篇，论文引用4700余次，H指数34，申请发明专利10项；主持/参与国家自然科学基金、美国CCFA基金会基金、科技部重点研发计划、企业横向等项目10余项；担任Frontiers in Drug Delivery,现代生物技术研究副主编；Asian Journal of Pharmaceutical Sciences (IF: 10.2), Chinese Chemical Letters (IF: 9.1), Exploration, Pharmaceutical Science Advances, Journal of Analysis and Testing, Nano TransMed, Interdisciplinary Medicine等杂志青年编委；Nature Nanotechnology, Med, Advanced Materials, ACS nano等多个杂志评审专家；中国医学装备协会组织再生分会常务委员，中国抗癌协会肠病专业委员会委员，中国研究型医院学会细胞外囊泡研究与应用专业委员会(CSEV)委员，中国民族医药学会远程教育分会常务理事，陕西省抗癌协会整合肿瘤免疫治疗分会常委。
研究领域及方向：
以组织器官损伤修复(肠道、肝、肾、大脑等)为主要目标，在炎症、缺血、纤维化等不同病理状态下，探究组织器官损伤修复的有序调控与干预策略，主要包括：
1. 损伤修复障碍的病理基础及分子机制研究；
2. 中草药衍生囊泡及其应用；
3. 中草药衍生碳基纳米酶及其应用；
4. 中草药活性分子的靶向递送。
纳米中药与组织损伤修复调控
学习工作简历：
2009年09月－2014年06月：博士，华中科技大学；
2014年09月－2017年10月：博士后，美国佐治亚州立大学；
2017年11月－2018年03月：研究助理教授，美国佐治亚州立大学生物医学研究院；
2018年03月－至今：特聘研究员/博导，西安交通大学基础医学院。
科研项目：
主持/参与国家自然科学基金、美国CCFA基金会基金、国家重点研发计划、陕西省自然科学基金，企业横向等项目。
联系方式：
电话/微信：17765089956
电子邮箱：mzhang21@xjtu.edu.cn
联系地址：西安交通大学创新港21号楼
个人主页：http://gr.xjtu.edu.cn/web/mzhang21
代表性论文：
1. Zhang MZ* et al.Robust reactive oxygen species modulator hitchhiking yeast microcapsule for colitis alleviation by trilogically intestinal microenvironment renovation.Bioactive Materials. 2024.
2. Zhang MZ* et al.Platelet-inspired nanomedicine targeting activated neutrophils to alleviate ulcerative colitis by free radicals scavenging and controlled neutrophil swarming.Nano Today. 2024, 54: 102139.
3. Zhang MZ* et al.Carbon dots enhanced peroxidase-like activity of platinum nanozyme.Nanoscale. 2024, 16: 4637-4646.
4. Zhang MZ* et al.Deciphering the catalytic mechanism of superior superoxide dismutase activity of carbon dot nanozyme.Nature Communications.2023, 14: 160.
5. Zhang MZ* et al.Versatile carbon dots with superoxide dismutase-like nanozyme activity and red fluorescence for inflammatory bowel disease therapeutics.Carbon. 2023, 204: 526-537.
6. Zhang MZ* et al.Integrating Pt nanoparticles with carbon nanodots to achieve robust cascade superoxide dismutase-catalase nanozyme for antioxidant therapy.Nano Today. 2023, 49: 101768.
7. Zhang MZ* et al.Reactive Oxygen Species-Responsive Nanocarrier Ameliorates Murine Colitisby Intervening Colonic Innate and Adaptive Immune Responses.Molecular Therapy. 2023, 31(5):1383-1401.
8. Zhang MZ* et al.A cascade nanoreactor for enhancing sonodynamic therapy on colorectal cancer via synergistic ROS augment and autophagy blockage.Nano Today. 2023, 49: 101798.
9. Zhang MZ* et al.Oral delivery of therapeutic andrographolide/carbon monoxide (CO) donor for synergistic treatment of ulcerative colitis by anti-inflammation and pro-resolution.ACS Applied Materials & Interfaces. 202315, 30, 36061–36075.
10. Zhang MZ* et al.Biomimetic nanoreactors for combinational chemo/chemodynamic therapy of choriocarcinoma through synergistic apoptosis and ferroptosis strategy.Chemical Engineering Journal. 2023, 472: 144690.
11. Zhang MZ* et al.Biomimetic redox-responsive prodrug micelles with diselenide linkage for platinum nanozymes augmented sonodynamic/chemo combined therapy of colon cancer.Chemical Engineering Journal. 2023, 472: 144911.
12. Zhang MZ* et al.Immune adjuvant functionalized biomimetic nanocarriers combine sonodynamic therapy for enhanced cancer immunotherapy.Chemical Engineering Journal. 2023, 476: 145685.
13. Zhang MZ* et al.Biosensing intestinal alkaline phosphatase by pregnancy test strips based on target-triggered CRISPR-Cas12a activity to monitor intestinal inflammation.Analytical Chemistry.2023, 95(37): 14111–14118.
14. Zhang MZ* et al.Metal polyphenol network/cerium oxide artificial enzymes therapeutic nanoplatform for MRI/CT imaging-aided intestinal inflammation management.Nano Today. 2023, 53: 102044.
15. Zhang MZ* et al.Macrophage-biomimetic liposomes delivery of carbon dots nanozymes ameliorate ulcerative colitis by modulating inflammation pathways and remodeling the redox microenvironment.Chemical Engineering Journal. 2023, 477: 146796.
16. Zhang MZ* et al.Carbon dot nanozymes as free radicals scavengers for the management of hepatic ischemia-reperfusion injury by regulating the liver inflammatory network and inhibiting apoptosis.Journal of Nanobiotechnology.2023, 21:500.
17. Zhang MZ* et al.Orally administration of cerium oxide nanozyme for computed tomography imaging and anti-inflammatory/anti-fibrotic therapy of inflammatory bowel disease.Journal of Nanobiotechnology. 2023, 21: 21.
18. Zhang MZ* et al.Point-of-care monitoring of dry eye disease using lysozyme in tear based on commercial pregnancy test strips.Sensors and Actuators B-Chemical. 2023, 378: 133179.
19. Zhang MZ* et al.Plant-derived vesicle-like nanoparticles: clinical application exploration and challenges.International Journal of Nanomedicine.2023, 18: 5671-5683.
