李海韵，副教授/博士生导师  

研究领域（方向）

1.炎症与天然免疫

2.内源损伤分子模式激活免疫系统的分子机制

3.组织损伤再生调控

教育与工作经历

2019.11 - 至今，西安交通大学 副教授

2017.12-2018.12，美国 哈佛医学Harvard Medical School 访问学者

2016.01 - 至2019.11，西安交通大学 讲师

2014.01-2016.01，清华大学 生命科学学院 博士后

2008.09-2013.12，兰州大学 生命科学学院 博士

2004-09-2008.06，兰州大学 生命科学学院 学士

主持科研项目

1. 国家自然科学基金面上项目，2023.01-2026.12，主持

2. 国家自然科学基金青年项目，2019.01-2021.12，主持

3. 中国博士后基金特别资助，2018T111039，主持

4. 中国博士后基金面上一等资助，2014M560075 ，主持

5. 清华-北大生命科学联合中心（CLS）优秀博士后基金

6. 陕西省自然科学基金（青年），2017JQ3026，主持

7. 西安交通大学基本科研业务费，xzy012019080，主持

8. 秦农银行-西安交大新冠专项项目，QNXJTU-08，主持

代表性论文

1. Li H.-Y., Tang C.-M., Wang Z, Lv J.-M., Liu X.-L., Liang Y.-L., Cheng B., Gao N., Ji S.-R.*, Wu Y.* (2022) C-Reactive Protein Protects Against Acetaminophen-Induced Liver Injury by Preventing Complement Overactivation. Cell Mol Gastroenterol Hepatol. 13(1):289-307.

2. Li H.-Y., Xiao-Ling Liu, Yu-Tong Liu, Zhe-Kun Jia, János G. Filip, Lawrence A. Potempa, Ji S.-R., Wu Y.*. (2019) Matrix sieving-enforced retrograde transcytosis regulates tissue accumulation of C-reactive protein. Cardiovascular Research. 115(2): 440-452.

3. Li Q.-Y. #, Li H.-Y. #, Fu G., Yu F. *, Wu Y. *, Zhao M-H（2017）Autoantibodies against C-Reactive Protein Influence Complement Activation and Clinical Course in Lupus Nephritis. Journal of the American Society of Nephrology, 28: 3044–3054. (Co-first author)

4. Lv J.-M., Huang X.-P., Jun-Yao Chen, Cheng B., Chen W.-Z., Yuan P., Wu F. *, Li H.-Y. * (2022) Cholesterol-binding sequence is a key regulatory motif of cellular folding and conformational activation for C-reactive protein. Molecular Immunology, 152 (2022) 123–128.

5. Yao Y.-Q.#, Li H.-Y. #, Qiu L, Shi J-M, Chen S-L, Qiu Y-J, Yu X, Qiang H, Yang Y-N, Facilitated methanogenesis involved in anaerobic digestion of dairy manure by soil. Journal of Cleaner Production, 236 (2019) 117640. (Co-first author)

6. Naeem U, Fu-Rong M, Jin H, Xiao-Ling L, Yu F, Yu-Tong L, Yu-Lin L, Hanyue Ouyang, and Li H.-Y.*（2020）Monomeric C-reactive protein regulates fibronectin mediated monocyte adhesion. Molecular Immunology, 117 (2020) 122–130.

7. Li H.-Y., Wang J., Meng F., Jia Z.-K., Su Y., Bai Q.-F., Lv L.-L., Ma F.-R., Potempa L.A., Ji S.-R.*, Wu Y.* (2016) An intrinsically disordered motif mediates diverse actions of monomeric C-reactive protein. Journal of Biological Chemistry, 15;291(16):8795-804. (recommended by Faculty of 1000)

8. Leng X.-Y.#, Li H.-Y.#, Wang J., Qi L.-B., Xi Y.-B., Yan Y.-B. * (2016) Congenital microcornea-cataract syndrome-causing mutation X253R increases βB1-crystallin hydrophobicity to promote aggregate formation. Biochemical journal, 10.1042 (Co-first author)

9.  Li H.-Y., Wang J., Wu Y.-X., Zhang L., Liu Z.-P., Filep J.G., Potempa L.A., Wu Y.*, Ji S.-R.* (2014) Topological localization of monomeric C-reactive protein determines pro-inflammatory endothelial cell responses. Journal of Biological Chemistry, 289(20): 14283-14290. (IF 5.16)

10. Qi L.-B., Hu L.-D., Liu H.-H., Li H.-Y. Leng X.-Y. Yan Y.-B.* (2016) Cataract-causing mutation S228P promotes βB1-crystallin aggregation and degradation by separating two interacting loops in C-terminal domain. Protein & Cell, 7: 501-515

联系方式

联系邮箱：lihaiy@xjtu.edu.cn / lihaiy61@163.com

联系地址：西安市雁塔西路76号西安交通大学医学部

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