陈乔依，研究员/博士生导师
研究领域：分子癌症学、表观遗传学、毒理学
课题组主要培养方向为癌症发生发展的表观遗传机制研究，其中包括组蛋白变体、染色质结构、外泌体信号通路、非编码RNA在DNA复制、基因转录、基因组稳定性维持等过程中发挥的重要作用。
个人履历
2020 至 今， 西安交通大学，医学部 基础医学院，特聘研究员“青年拔尖人才计划”
2019 至 2020， 美国纽约大学，Research Scientist
2014 至 2019， 美国纽约大学，博士, Kirschstein NRSA (NIH) 奖学金
2010 至 2014， 美国堪萨斯大学，学士
主持基金
2020 至 2023， 陕西省自然科学基金，主持，在研
2020 至 2026， 西安交通大学青年拔尖人才，主持，在研
个人简介
2014年于美国堪萨斯大学获学士学位；2019年于美国纽约大学获博士学位；同年留校担任纽约大学医学院Research Scientist。2020年3月来校工作，现担任西安交通大学研究员、博士生导师，主持陕西省自然科学基金1项；西安交通大学“青年拔尖人才计划” 基金1项。已发表SCI论文29篇，其中以第一作者或通讯作者发表22篇，包括国际肿瘤学和卫生毒理学专业期刊Annual Review of Pharmacology and Toxicology、Environmental Pollution、Molecular Pharmacology、Carcinogenesis、iScience等。
部分研究论文
Qin X, Wu P, Wen T, Jia R, Zhang R, Jin J, Hu F, Chen QY#, Dang J#. Comparative Assessment of Blood Metal/metalloid levels, Clinical Heterogeneity, and Disease Severity in Amyotrophic Lateral Sclerosis Patients. Neurotoxicology. 2022 Jan 7.
Wen T, Chen QY#. Dynamic Activity of Histone H3-Specific Chaperone Complexes in Oncogenesis. Frontiers in Oncology. 2021;11.
Song Q, Gao Q, Chen T, Wen T, Wu P, Luo X, Chen QY#. FAM3A Ameliorates Brain Impairment Induced by Hypoxia–Ischemia in Neonatal Rat. Cellular and Molecular Neurobiology. 2021 Dec 1:1-4.
Chen QY, Costa M. Arsenic: a global environmental challenge. Annual review of pharmacology and toxicology. 2021 Jan 6;61:47-63.
Chen QY#, Wen T, Wu P, Jia R, Zhang R, Dang J. Exosomal Proteins and miRNAs as Mediators of Amyotrophic Lateral Sclerosis. Frontiers in Cell and Developmental Biology. 2021:2443.
Chen QY#, Xie X. Association of Exosomal miR-210 with Signaling Pathways Implicated in Lung Cancer. Genes. 2021 Aug;12(8):1248.
Jia R, Chen QY, Zhou Q, Zhang R, Jin J, Hu F, Liu X, Qin X, Kang L, Zhao S, Dang Y. Characteristics of serum metabolites in sporadic amyotrophic lateral sclerosis patients based on gas chromatography-mass spectrometry. Scientific Reports. 2021 Oct 21;11(1):1-1.
Zhu Y, Chen QY, Jordan A, Sun H, Roy N, Costa M. RUNX2/miR‑31/SATB2 pathway in nickel‑induced BEAS‑2B cell transformation. Oncology Reports. 2021 Aug 1;46(2):1-6.
Jin J, Hu F, Zhang Q, Chen QY, Li H, Qin X, Ji R, Kang L, Dang Y, Dang J. The degeneration of upper and lower motor neuron from the perspective of clinical neurological examination and MRI-electromyography manifold detection in amyotrophic lateral sclerosis. NeuroReport. 2021 Jan 6;32(1):23-8.
Chen D*, Chen QY*, Wang Z, Zhu Y, Kluz T, Tan W, Li J, Wu F, Fang L, Zhang X, He R. Polyadenylation of histone H3. 1 mRNA promotes cell transformation by displacing H3. 3 from gene regulatory elements. Iscience. 2020 Sep 25;23(9):101518.
Chen QY, Shen S, Sun H, Wu F, Kluz T, Kibriya MG, Chen Y, Ahsan H, Costa M. PBMC gene expression profiles of female Bangladeshi adults chronically exposed to arsenic-contaminated drinking water. Environmental Pollution. 2020 Apr 1;259:113672.
Chen QY, Murphy A, Sun H, Costa M. Molecular and epigenetic mechanisms of Cr (VI)-induced carcinogenesis. Toxicology and applied pharmacology. 2019 Aug 15;377:114636.
Chen QY, Des Marais T, Costa M. Deregulation of SATB2 in carcinogenesis with emphasis on miRNA-mediated control. Carcinogenesis. 2019 Mar;40(3):393-402.
Chen QY, DesMarais T, Costa M. Metals and mechanisms of carcinogenesis. Annual review of pharmacology and toxicology. 2019 Jan 6;59:537.
Jin J, Hu F, Zhang Q, Chen QY, Li H, Qin X, Jia R, Kang L, Dang Y, Dang J. Dominant heterogeneity of upper and lower motor neuron degeneration to motor manifestation of involved region in amyotrophic lateral sclerosis. Scientific reports. 2019 Dec 27;9(1):1-8.
Hu F, Jin J, Chen QY, Kang L, Jia R, Qin X, Liu X, Dang Y, Dang J. Dissociated lower limb muscle involvement in amyotrophic lateral sclerosis and its differential diagnosis value. Scientific Reports. 2019 Nov 28;9(1):1-8.
Zhu Y, Chen QY, Li AH, Costa M. The role of non-coding RNAs involved in nickel-induced lung carcinogenic mechanisms. Inorganics. 2019 Jul;7(7):81.
Li J, Chen Y, Chen QY, Liu D, Xu L, Cheng G, Yang X, Guo Z, Zeng Y. Role of transient receptor potential cation channel subfamily V member 1 (TRPV1) on ozone-exacerbated allergic asthma in mice. Environmental Pollution. 2019 Apr 1;247:586-94.
Chen QY, Li J, Sun H, Wu F, Zhu Y, Kluz T, Jordan A, DesMarais T, Zhang X, Murphy A, Costa M. Role of miR‐31 and SATB2 in arsenic‐induced malignant BEAS‐2B cell transformation. Molecular carcinogenesis. 2018 Aug;57(8):968-77.
Chen QY, Costa M. PI3K/Akt/mTOR signaling pathway and the biphasic effect of arsenic in carcinogenesis. Molecular pharmacology. 2018 Jul 1;94(1):784-92.
Chen QY, Costa M. Oncogenic and tumor suppressive roles of special
联系方式
通信地址： 西安交通大学基础医学院
西咸新区中国西部科技创新港
21号楼4-4048室
电子邮箱： qychen203@xjtu.edu.cn
个人主页：https://gr.xjtu.edu.cn/en/web/qychen203
