校蕾

西安交通大学医学部,教授,博士生导师

血管医学与代谢生物学研究团队负责人

邮箱:xiaolei0122@xjtu.edu.cn

电话:18609284536

 

学习、工作经历:

2024.01~ 西安交通大学医学部,教授

2018.01~2023.12  西安交通大学医学部,副教授
2012.07~2017.12  西安交通大学医学部,讲师

2014.04~2015.04  美国俄克拉荷马大学,进修
2015.05~2016.05  美国佐治亚州立大学,进修

2007.09~2012.07  北京师范大学,生理学博士

2003.09~2007.07  西北大学,生物学学士

研究方向:

心血管及代谢性疾病基础研究,受体与信号转导,天然营养素与血管功能,免疫炎症性皮肤病机制

1. 主持科研项目情况:

[1] 国家自然科学基金重点项目(批准号82230012),合作主持

[2] 国家自然科学基金重大研究计划培育项目(批准号91939108),主持
[3]
国家自然科学基金面上项目(批准号81770497),主持

[4] 西安交通大学医学基础-临床融合创新项目(批准号YXJLRH2022024),合作主持

[5] “医学攀登人才计划﹣医学部首批国家级后备人选支持计划(No.217),主持

2. 近五年以第一/通讯作者发表论文情况:

[1] Cui, Q., Jiang, T., Xie X., Wang, H., Qian L., Cheng Y., Li Q., Lu, T., Yao, Q., Liu, J., Lai, B., Chen, C., Xiao, L.*, Wang, N.*, 2023. S-nitrosylation Attenuates Pregnane X Receptor Hyperactivity and Acetaminophen-induced Liver Injury. JCI Insight. e172632. IF: 8

[2] Xie, X#, Cui, Q#, Jiang, T., Zhao, Z., Liu, Z., Liu, J., Yao, Q., Wang, Y., Dang, E., Wang, G., Xiao, L.*, Wang, N., 2023. A Critical Role of Endothelial Skp2/PTEN Axis in Angiogenesis and Psoriasis. Br J Dermatol. Oct 18:ljad399. IF: 10.3

[3] 崔琪,杜雄,校蕾*,汪南平*. 2023. 转录因子的巯基亚硝基化修饰及其生理学意义,生理科学进展54, 26-32.

[4] Xiao, L., Wang, N.*, 2022. PPAR-δ: A key nuclear receptor in vascular function and remodeling. J Mol Cell Cardiol. 169, 1-9. IF: 5

[5] Liu, J.#, Du, X.#, Yao, Q., Jiang, T., Cui, Q., Xie, X., Zhao, Z., Lai, B., Wang, N., Xiao, L.*, 2022. Procyanidin B2 ameliorates endothelial dysfunction induced by nicotine via the induction of tetrahydrobiopterin synthesis, J Funct Foods., 99, 105306. IF: 6.1

[6] Lai, B #, Xie, X.#, Li, F.#, Cui, Q., Dang, E., Luo, W., Wang, N., Zheng, Y., Wang, G., Xiao, L.*, Wang, N., 2021. Xenobiotic Receptor CAR Is Highly Induced in Psoriasis and Promotes Keratinocyte Proliferation. J Invest Dermatol. 141, 2895-2907.e2897. IF: 6.5

[7] Xiao, L., Nie, X., Cheng, Y., Wang, N.*, 2021. Sodium-Glucose Cotransporter-2 Inhibitors in Vascular Biology: Cellular and Molecular Mechanisms. Cardiovasc Drugs Ther. 35, 1253-1267. IF: 3.4

[8] Nie, X.#, Tang, W.#, Zhang, Z., Yang, C., Qian, L., Xie, X., Qiang, E., Zhao, J., Zhao, W., Xiao, L.*, Wang, N.*, 2020. Procyanidin B2 mitigates endothelial endoplasmic reticulum stress through a PPARδ-Dependent mechanism. Redox Biol. 37, 101728. IF: 11.4

[9] Zhang, Z., Xie, X., Yao, Q., Liu, J., Tian, Y., Yang, C., Xiao, L.*, Wang, N.*, 2019a. PPARδ agonist prevents endothelial dysfunction via induction of dihydrofolate reductase gene and activation of tetrahydrobiopterin salvage pathway. Br J Pharmacol. 176, 2945-2961. IF:7.3

[10] Xie, X.#, Yang, C.#, Cui, Q., Ma, W., Liu, J., Yao, Q., Zhang, Z., Xiao, L.*, Wang, N.*, 2019b. Stachydrine Mediates Rapid Vascular Relaxation: Activation of Endothelial Nitric Oxide Synthase Involving AMP-Activated Protein Kinase and Akt Phosphorylation in Vascular Endothelial Cells. J Agric Food Chem. 67, 9805-9811. IF:6.1

[11] Tian, Y., Yang, C., Yao, Q., Qian, L., Liu, J., Xie, X., Ma, W., Nie, X., Lai, B., Xiao, L.*, Wang, N.*, 2019c. Procyanidin B2 Activates PPARγ to Induce M2 Polarization in Mouse Macrophages. Front Immunol. 10, 1895. IF:7.3

[12] Zhang, M., Zhang, Z., Xie, X., Yao, Q., Liu, J., Lai, B., Xiao, L.*, Wang, N.*, 2019d. Xenobiotic pregnane X receptor promotes neointimal formation in balloon-injured rat carotid arteries. J Cell Physiol. 234, 4342-4351. IF:5.6

3. 论文获奖情况:

[1] 2023 国际皮肤病研究学会学术会议(ISID 旅行资助奖(日本东京)

[2] 2018亚洲血管生物学会(ASVB)青年优秀奖第二名(中国上海)

[3] 2018南方国际心血管病学术会议优秀论文二等奖(中国广州)


4. 学术兼职:
中国病理生理学会 理事
中华医学会心血管病学分会代谢性心血管疾病学组 委员
中国病理生理学会受体专业委员会 委员
中国病理生理学会血管医学专业委员会 青年委员
中国生物化学与分子生物学会脂质与脂蛋白专业委员会 青年委员