李海
博士，教授，博士生导师
研究领域（方向）
（1）疫苗免疫应答机理与调控；
（2）生命早期免疫；
（3）抗病毒靶向治疗；
（4）溶瘤病毒。
学习与研究经历
2022年1月－至今 西安交通大学基础医学院 教 授 博导
2014年9月－2021年12月 中国农业科学院哈尔滨兽医研究所 研究员 博导
2008年6月－2014年5月 瑞典卡罗林斯卡医学院 医学博士
2004年9月－2009年6月 中国农业大学 农学博士
基本信息
2014年入选中国农业科学院“青年英才计划（A类）”，回国到哈尔滨兽医研究所兽医生物技术国家重点实验室工作，任研究员，博士生导师，学委会委员；2022年1月至今任西安交通大学基础医学院教授，博士生导师，入选西安交通大学“青年拔尖人才支持计划（A类）”。任中国畜牧兽医学会兽医公共卫生分会理事，中国微生物学会兽医微生物专业委员会青年委员，美国免疫学会（AAI）会员，国家、黑龙江省及江苏省基金同行评审专家，教育部学位论文网评专家等。兼任Cellular & Molecular Immunology、Frontiers in Immunology等期刊审稿专家。
科研成果
主持国家自然科学基金面上项目、黑龙江省杰出青年基金项目等各级科研项目十余项。在Cell Death & Differentiation，PLoS Pathogens，Journal of Virology，Journal of Immunology等学术期刊发表SCI论文27篇，JCR 1区18篇。授权国家发明专利5件。培养研究生17人，3人获国家奖学金。
代表性论文
1. Xu Li, Chen Zhijie, Zhang Yu, Cui Lu, Liu Zheyi, Li Xuefeng, Liu Shengwang*, Hai Li*. P53 maintains gallid alpha herpesvirus 1 replication by direct regulation of nucleotide metabolism and ATP synthesis through its target genes. Frontiers in Microbiology, 2022(13), 1044141. (https://doi.org/10.3389/fmicb.2022.1044141)
2. Zhijie Chen, Lu Cui, Li Xu, Zheyi Liu, Yumeng Liang, Xuefeng Li, Yanhui Zhang, Yijing Li, Shengwang Liu, Hai Li*. Characterization of chicken p53 transcriptional function via parallel genome-wide chromatin occupancy and gene expression analysis. Poultry Science. 2022, 102164. (https://doi.org/10.1016/j.psj.2022.102164.)
3. Li Xu, Zhitao Wang, Zhijie Chen, Lu Cui, Zheyi Liu, Yumeng Liang, Xuefeng Li, Yanhui Zhang, Shengwang Liu*, Hai Li*. PFT-α inhibits gallid alpha herpesvirus 1 replication by repressing host nucleotide metabolism and ATP synthesis. Veterinary Microbiology. 2022(269), 109435. (https://doi.org/10.1016/j.vetmic.2022.109435.)
4. Yumeng Liang#, Yong Ma#, Yanhui Zhang, Zhijie Chen, Zhitao Wang, Xuefeng Li, Lu Cui, Li Xu, Shengwang Liu*, Hai Li*. Single-Cell Analysis of the In Vivo Dynamics of Host Circulating Immune Cells Highlights the Importance of Myeloid Cells in Avian Flaviviral Infection. Journal of Immunology. December 1, 2021, 207 (11) 2878-2891; DOI: https://doi.org/10.4049/jimmunol.2100116. PMID: 34697228.
5. Lu Cui#, Yong Ma#, Yumeng Liang, Yanhui Zhang, Zhijie Chen, Zhitao Wang, Hanguang Wu, Xuefeng Li, Li Xu,, Shengwang Liu*, Hai Li*. Polarization of avian macrophages upon avian flavivirus infection. Veterinary Microbiology. 2021; 256:109044. DOI: 10.1016/j.vetmic.2021.109044.
6. Zhitao Wang#, Yangyang Qiao#, Zhijie Chen, Yumeng Liang, Lu Cui; Yanhui Zhang, Xuefeng Li, Li Xu, Ping Wei, Shengwang Liu*, Hai Li*. Fos Facilitates Gallid Alpha-Herpesvirus 1 Infection by Transcriptional Control of Host Metabolic Genes and Viral Immediate Early Gene. Viruses. 2021 Jun 9;13(6):1110. doi: 10.3390/v13061110.
7. Yangyang Qiao#, Zhitao Wang#, Zhongxi Han, Yuhao Shao, Yong Ma, Yumeng Liang , Zhijie Chen , Hanguang Wu , Lu Cui , Yanhui Zhang , Shengwang Liu*, Hai Li*. Global exploration of the metabolic requirements of gallid alphaherpesvirus 1. PLoS Pathogens. 2020;16(8): e1008815.
8. Yong Ma, Yumeng Liang, Nana Wang, Lu Cui, Zhijie Chen, Hanguang Wu, Chenyang Zhu, Zhitao Wang, Shengwang Liu*, Hai Li*. Avian Flavivirus Infection of Monocytes/Macrophages by Extensive Subversion of Host Antiviral Innate Immune Responses. Journal of Virology. 2019;93(22). pii: e00978-19. Print 2019 Nov 15. DOI: 10.1128/JVI.00978-19
9. Zhitao Wang, Bangyao Sun, Qi Gao, Yong Ma, Yumeng Liang, Zhijie Chen, Hanguang Wu, Lu Cui, Yuhao Shao, Ping Wei*, Hai Li*, Shengwang Liu*. Host Src controls gallid alpha herpesvirus 1 intercellular spread in a cellular fatty acid metabolism-dependent manner. Virology. 2019 (537):1-13. DOI: 10.1016/j.virol.2019.08.011.
10. Hai Li#, Qi Gao#, Yuhao Shao, Bangyao Sun, Fengjie Wang, Yangyang Qiao, Nana Wang, Shengwang liu*. Gallid Herpesvirus 1 Intitates Apoptosis in Uninfected Cells through Paracrine Repression of p53. Journal of Virology. 2018; 92(18):e00529-18. DOI: 10.1128/JVI.00529-18.
11. Yu Zhang#, Chenyang Zhua#, Bangyao Sun, Jiawei Lv, Zhonghua Liu*, Shengwang Liu*, Hai Li*. Integrated high throughput analysis identifies GSK3 as a determinant of p53-mediated apoptosis in lung cancer cells. Cellular Physiology and Biochemistry. 2017;42:1177-91. DOI: 10.1159/000478873.
12. Hai Li#, Fengjie Wang #, Zongxi Han, Qi Gao, Huixin Li, Yuhao Shao, Nana Sun, Shengwang liu*. Genome-wide gene expression analysis identifies the proto-oncogene tyrosine-protein kinase Src as a crucial virulence determinant of the infectious laryngotracheitis virus in chicken cells. Journal of Virology. 2016;90(1):9-21. DOI: 10.1128/JVI.01817-15.
13. Yu Zhang#, Jing Ma#, Hai Li#, Jiawei Lv, Renyue Wei, Yimei Cong, Zhonghua Liu*. bFGF signaling-mediated reprogramming of porcine primordial germ cells. Cell and Tissue Research. 2016;364(2): 429-441. DOI: 10.1159/000478873.
14. Yu Zhang#, Hai Li#, Renyue Wei, Jing Ma, Yanhua Zhao, Zhengxing Lian*, Zhonghua Liu*. Endothelial Cell Regulates Cardiac Myocyte Reorganization through β1-integrin Signaling. Cell Physiol Biochem. 2015;35(5):1808-20.
15. Hai Li, Yu Zhang, Anda Ströse, Yao Shi, Donato Tedesco, Katerina Gurova, Galina Selivanova*. Integrated high throughput analysis identifies Sp1 as a crucial determinant of p53-mediated apoptosis. Cell Death & Differentiation. 2014;21(9):1493-502.
16. Hai Li, Yu Zhang, Galina Selivanova*. Integrated high throughput analysis identifies AP-1 as a crucial factor of p53-mediated cell fate decision. Journal of Biotechnology. 2014 (185S) 89.
17. Shi Y, Nikulenkov F, Zawacka-Pankau J, Li H, Gabdoulline R, Xu J, Eriksson S, Hedström E, Issaeva N, Kel A, Arnér E, Selivanova G*. ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis. Cell Death & Differentiation. 2014;21(4):612-23.
18. Hai Li, Lakshmikanth Tadepally, Ennio Carbone*, and Galina Selivanova*. A novel facet of tumor suppression by p53: induction of tumor immunogenicity. Oncoimmunology. 2012;1(4):541-543.
19. F Nikulenkov, C Spinnler#, H Li#, C Tonelli, Y Shi, M Turunen, T Kivioja, I Ignatiev, A Kel, J Taipale, G Selivanova*. Insights into p53 transcriptional function via genome-wide chromatin occupancy and gene expression analysis. Cell Death & Differentiation. 2012;19(12):1992-2002.
20. Hai Li, Tadepally Lakshmikanth, Cinzia Garofalo, Martin Enge, Clemens Spinnler, Andrea Anichini, Laszlo Szekely, Klas Kärre, Ennio Carbone*, Galina Selivanova*. Pharmacological activation of p53 triggers anticancer innate immune response through induction of ULBP2. Cell Cycle. 2011;10(19):3346-58.
21. Spinnler C, Hedström E, Li H, de Lange J, Nikulenkov F, Teunisse AF, Verlaan-de Vries M, Grinkevich V, Jochemsen AG, Selivanova G*. Abrogation of Wip1 expression by RITA-activated p53 potentiates apoptosis induction via activation of ATM and inhibition of HdmX. Cell Death & Differentiation. 2011;18(11):1736-45.
22. Joanna Zawacka-Pankau, Vera V Grinkevich, Sabine Hünten, Fedor Nikulenkov, Angela Gluch, Hai Li, Martin Enge, Alexander Kel, Galina Selivanova*. Inhibition of glycolytic enzymes mediated by pharmacologically activated p53: targeting Warburg effect to fight cancer. J Biol Chem. 2011;286(48):41600-15.
23. Yu Zhang, Hai Li, Zhengxing Lian*, Ning Li*. Myofibroblasts protect myoblasts from intrinsic apoptosis associated with differentiation via beta 1 integrin-PI3K/Akt pathway. Dev Growth Differ. 2010;52(8):725-33. DOI: 10.1111/j.1440-169X.2010.01209.x
24. Yu Zhang, Hai Li, Zhengxing Lian*, Ning Li*. Normal fibroblasts promote myodifferentiation of myoblasts from sex-linked dwarf chicken via up-regulation of beta 1 integrin. Cell Biol Int. 2010;34(11):1119-27. DOI: 10.1042/CBI20090351
25. Hai Li, Yu Zhang, Shifeng Zuo, Zhengxing Lian*, Ning Li*. Effects of methyltestosterone on immunity against Salmonella Pullorum in dwarf chicks. Poult Sci. 2009;88(12):2539-48.
26. Hai Li, Yu Zhang, Zhonghua Ning, Xuemei Deng, Zhengxing Lian*, Ning Li*. Effect of selection for phagocytosis in dwarf chickens on immune and reproductive characters. Poult. Sci. 2008;87:41-49.
27. Shufeng Sun, Qiuzhen Pan, Xue Hui, Baolu Zhang, Hongmei Wu, Hai Li, W Xu, Qin Zhang, Jinyin Li, Xuemei Deng, Jinwen Chen, Zhengxing Lian and Ning Li. Stronger in vitro phagocytosis by monocytes-macrophages is indicative of greater pathogen clearance and antibody levels in vivo. Poult. Sci. 2008;87:1725-1733.
联系方式
联系地址：陕西省西安市中国西部创新港21号楼
E-mail：lihai@xjtu.edu.cn
