姓名：姚婷
一级学科：生物学
研究领域（方向）：
主要从事代谢网络调控、稳态维持与异常发生机制研究，具体包括：
（1）下丘脑调控代谢的神经生理机制；
（2）代谢调控网络的跨器官互作研究。
个人及工作简历：
教育经历：
（1）2013-09至2017-09，西安交通大学，生理学，博士；
（2）2014-09至2017-08，美国德州大学西南医学中心，神经内分泌，联合培养博士；
（3）2008-09至2011-07，第四军医大学，劳动卫生与环境卫生学，硕士；
（4）2002-09至2006-07，第四军医大学，生物医学工程，学士。
博士后工作经历：
（1）2017-09至2020-10，加州大学洛杉矶分校。
科研与学术工作经历（博士后工作经历除外）：
（1）2021-07至今，西安交通大学，基础医学院，副教授；
（2）2012-09至2013-09，南方医科大学，基础医学院，助理研究员；
（3）2011-09至2012-09，第四军医大学，军事预防医学院，讲师；
（4）2006-09至2011-09，第四军医大学，军事预防医学院，助教。
主要科研项目1.小胶质细胞内质网应激分子IRE1α调控肥胖发生发展作用与机制，国家自然科学基金面上项目，2023.01-2026.12，项目负责人
2.解析“中枢-外周”组织器官间的免疫代谢对话机制，“四大慢病”国家课题，2025.02-2029.01，课题负责人
代表性论著、科研获奖、人才称号1. Yao T, Wu G, Zeng Y, Xie Y, Cui X, Zhang Q, Yan C, Cui Z, Gong H, Xiong T, Liang X, Zhang Y, Zheng R, Wang H, Gao M, Zhang P, Wang R, Zhao X, Feng Z, Xiao L, Liu T, Zhang Z. Hypothalamic malate dehydrogenase 2 modulates systemic glucose metabolism through oxytocin-mediated thermogenesis. Cell Reports Medicine, 2026.
2. Yao T, Wang H, Lin K, Wang R, Guo S, Chen P, Wu H, Liu T, Wang R. Exercise-induced microbial changes in preventing type 2 diabetes. Science China Life Sciences, 2024.
3. Lei Y, Liang X, Sun Y, Yao T, Gong H, Chen Z, Gao Y, Wang H, Wang R, Huang Y, Yang T, Yu M, Liu L, Yi CX, Wu QF, Kong X, Xu X, Liu S, Zhang Z, Liu T. Region-specific transcriptomic responses to obesity and diabetes in macaque hypothalamus. Cell Metabolism, 2024.（共同第一作者）
4. Yao T, Yan H, Zhu X, Zhang Q, Kong X, Guo S, Feng Y, Wang H, Hua Y, Zhang J, Mittelman SD, Tontonoz P, Zhou Z, Liu T, Kong X. Obese skeletal muscle-expressed interferon regulatory factor 4 transcriptionally regulates mitochondrial branched-chain aminotransferase reprogramming metabolome. Diabetes, 2022.（
5. Zhu X, Yao T, Wang R, Guo S, Wang X, Zhou Z, Zhang Y, Zhuo X, Wang R, Li JZ, Liu T, Kong X. IRF4 in skeletal muscle regulates exercise capacity via PTG/glycogen pathway. Advanced Science, 2020.（共同第一作者）
6. Wang R, Tian H, Guo D, Tian Q, Yao T#，Kong X#. Impacts of exercise intervention on various diseases in rats. Journal of Sport and Health Science, 2019.（#共同通讯作者）
7. Kaneko K, Fu Y, Lin HY, Cordonier EL, Mo Q, Gao Y, Yao T, Naylor J, Howard V, Saito K, Xu P, Chen SS, Chen MH, Xu Y, Williams KW, Ravn P, Fukuda M#. Gut-derived GIP activates central Rap1 to impair neural leptin sensitivity during overnutrition. Journal of Clinical Investigation, 2019.
8. Kong X, Yao T, Zhou P, Kazak L, Tenen D, Lyubetskaya A, Dawes BA, Tsai L, Kahn BB, Spiegelman BM, Liu T#，Rosen ED#. Brown adipose tissue controls skeletal muscle function via the secretion of myostatin. Cell Metabolism, 2018.（共同第一作者）
9. Huang Y, He Z, Gao Y, Lieu L, Yao T, Sun J, Liu T, Javadi C, Box M, Afrin S, Guo H, Williams KW#. Phosphoinositide 3-kinase is integral for the acute activity of leptin and insulin in male arcuate NPY/AgRP neurons. Journal of the Endocrine Society, 2018.
10. Yao T, Deng Z, Gao Y, Sun J, Kong X, Huang Y, He Z, Xu Y, Chang Y, Yu KJ, Findley BG, Berglund ED, Wang RT, Guo H, Chen H, Li X, Kaufman RJ, Yan J#，Liu T#，Williams KW#. Ire1αin Pomc neurons is required for thermogenesis and glycemia. Diabetes, 2017.
11. Shen WJ, Yao T, Kong X, Williams KW#，Liu T#. Melanocortin neurons: multiple routes to regulation of metabolism. Biochimica et Biophysica Acta, 2017.（共同第一作者）
12. Gaykema RP, Newmyer BA, Ottolini M, Raje V, Warthen DM, Lambeth PS, Niccum M, Yao T, Huang Y, Schulman IG, Harris TE, Patel MK, Williams KW, Scott MM#. Activation of murine pre-proglucagon-producing neurons reduces food intake and body weight. Journal of Clinical Investigation, 2017.
13. Gao Y, Yao T, Deng Z, Sohn JW, Sun J, Huang Y, Kong X, Yu KJ, Wang RT, Chen H, Guo H, Yan J, Cunningham KA, Chang Y#，Liu T#，Williams KW#. TrpC5 mediates acute leptin and serotonin effects via Pomc neurons. Cell Reports, 2017.（共同第一作者）
14. Sun J, Gao Y, Yao T, Huang Y, He Z, Kong X, Yu KJ, Wang RT, Guo H, Yan J, Chang Y, Chen H, Scherer PE, Liu T#，Williams KW#. Adiponectin potentiates the acute effects of leptin in arcuate Pomc neurons. Molecular Metabolism, 2016.（共同第一作者）
15. Zhu Y, Gao Y, Tao C, Shao M, Zhao S, Huang W, Yao T, Johnson JA, Liu T, Cypess AM, Gupta O, Holland WL, Gupta RK, Spray DC, Tanowitz HB, Cao L, Lynes MD, Tseng YH, Elmquist JK, Williams KW, Lin HV, Scherer PE#. Connexin 43 mediates white adipose tissue beiging by facilitating the propagation of sympathetic neuronal signals. Cell Metabolism, 2016.
16. Zhang J, Cao R, Cai T, Aschner M, Zhao F, Yao T, Chen Y, Cao Z, Luo W#，Chen J#. The role of autophagy dysregulation in manganese-induced dopaminergic neurodegeneration. Neurotoxicity Research, 2013.
17. Cai T, Che H, Yao T, Chen Y, Huang C, Zhang W, Du K, Zhang J, Cao Y, Chen J#，Luo W#. Manganese induces tau hyperphosphorylation through the activation of ERK MAPK pathway in PC12 cells. Toxicological Sciences, 2011.（共同第一作者）
18. Cai T, Yao T, Zheng G, Chen Y, Du K, Cao Y, Shen X, Chen J#，Luo W#. Manganese induces the overexpression of alpha-synuclein in PC12 cells via ERK activation. Brain Research, 2010.（共同第一作者）
19. Cai T, Yao T, Li Y, Chen Y, Du K, Chen J#，Luo W#. Proteasome inhibition is associated with manganese-induced oxidative injury in PC12 cells. Brain Research, 2007.
电子邮箱：yaoting@xjtu.edu.cn
