研究方向：
重要急性期蛋白的基础生物学及诊疗应用。
工作简历：
2003.08~2015.08，兰州大学生命科学学院，教授；
2015.08至今，西安交通大学基础医学院，教授。
科研项目：
主持国科金重点、优青、面上及科技部、教育部课题、陕西省重点研发计划等科研项目三十余项。
科研奖励：
国家自然科学奖二等奖（3/5）；
陕西省自然科学奖二等奖（1/5）；
陕西高等学校科学技术研究优秀成果奖一等奖（1/5）；
贝时璋青年生物物理学家奖。
学术任职：
Frontiers in Immunology副主编（2022至今）、Biophysics Reports副主编（2017至今）、生物物理学报副主编等；
国际动脉粥样硬化学会中国分会理事、中国生物物理学会膜生物学、冷冻电子显微学、分子生物物理学等分会理事、中国生物化学与分子生物学会蛋白质专业分会理事、陕西省实验动物学会常务理事等。
代表性论文：
1.Jena K.K., Qu P., Baracco L., Saghaei S., Keerti F., Allahyari Z., Boehmer D., Mitchell M., Dillen C.A., Li H.-Y., Liu E., Poli V., Dufies O., van Konijnenburg D.P.H., Spreafico R., Bi C., Hall R., Kruppa M.D., Ma Z., Gravitte A., Lowman D.W., Ensley H.E., Marty P., Boyer L., Collomp R., Williams D.L., Ma V. P.-Y, Lee P.Y., Nigrovic P.A., Karp J.M., Elledge S.J., Wesemann D.R.,Wu Y.*, Frieman M., Zanoni I.* (2026) A glycan-based adjuvant expands the breadth and duration of protection of mRNA-based vaccines.Nature Immunology,in press.
2.Fu Y., Hua Y.-X., Zhang Y.-L., Zhang C.-Y., Li H.-Y., Melnikov I, Gabbasov Z. A.,Wu Y.*, Liu E.-Q.*, Ji S.-R.* (2026) C-reactive protein exacerbates high-fat diet-induced atherosclerosis via a liver-to-vessel axis that determines therapeutic efficacy of atorvastatin.Atherosclerosis, 412: 120594.
3. Feng J.-R., Li X., Han C., Chang Y., Fu Y., Feng G.-C., Lei Y., Li H.-Y., Tang P.M.K., Ji S.-R.*, Hou Y.*,Wu Y.*(2024) C-Reactive protein induces immunosuppression by activating FcγR2B in pulmonary macrophages to promote lung metastasis.Cancer Research, 84(24): 4184-4198. (Featured article with commentary:https://aacrjournals.org/cancerres/article-abstract/84/24/4121/750405/C-Reactive-Protein-Facilitates-Premetastatic-Niche?redirectedFrom=fulltext)
4. Zhou L, Chen S.-J., Chang Y., Liu S.-H., Zhou Y.-F., Huang X.-P., Hua Y.-X., An H., Zhang S.-H., Melnikov I., Gabbasov Z. A.,Wu Y.*, Ji S.-R.* (2023) Monomeric C-reactive protein evokes TCR signaling-dependent bystander activation of CD4+ T cells.Molecular Immunology, 157(5): 158-166.
5. Ji S.-R.*, Zhang S.-H., Chang Y., Li H.-Y., Wang M.-Y., Lv J.-M., Zhu L., Tang P.M.K.,Wu Y.*(2023) C-reactive protein: the most familiar stranger.Journal of Immunology, 210(6): 699-707. (Invited review)
6. Li H.-Y., Tang Z.-M., Wang Z., Lv J.-M., Liu X.-L., Liang Y.-L., Cheng B., Gao N., Ji S.-R.*,Wu Y.*(2022) C-reactive protein protects against acetaminophen-induced liver injury by preventing complement overactivation.Cellular and Molecular Gastroenterology and Hepatology, 13(1): 289-307. (Featured article with commentary: https://www.sciencedirect.com/science/article/pii/S2352345X21002186)
7. Wang M.-Y., Zhang C.-M., Zhou H.-H., Ge Z.-B., Su C.-C., Lou Z.-H., Zhang X.-Y., Xu T.-T., Li S.-Y., Zhu L., Zhou Y.-L., Wu Y.*,Ji S.-R.*(2022) Identification of a distal enhancer that determines the expression pattern of acute phase marker C-reactive protein.Journal of Biological Chemistry, 298(8): 102160. (Editor’s Pick)
8. Cheng B., Lv J.-M., Liang Y.-L., Zhu L., Huang X.-P., Li H.-Y., Potempa L.A., Ji S.-R.*,Wu Y.*(2022) Secretory quality control constrains functional selection-associated protein structure innovation.Communications Biology, 5: 268.
9. Wang M.-Y., Zhou H.-H., Zhang C.-M., Su H.-X., Li S.-L., Ji S.-R., Liu E.-Q.*,Wu Y.*(2020) A functional genetic variant at C-reactive protein promoter (rs3091244) is not associated with cancer risk in a Chinese population.Frontiers in Immunology, 11: 926.
10. Liu Y., Yuan B., Peng L., Zhao J., Zhou Y., Xiang S., Zhu L.*,Wu Y.*(2020) Single-particle analysis of urea amidolyase reveals its molecular mechanism.Protein Science, 29(5): 1242-1249.
11. Zhang S.-C., Wang M.-Y., Feng J.-R., Chang Y., Ji S.-R.*,Wu Y.*(2020) Reversible promoter methylation determines fluctuating expression of acute phase proteins.eLife, 9: e51317.
12. Li H.-Y., Liu X.-L., Liu Y.-T., Jia Z.-K., Filep J.G., Potempa L.A., Ji S.-R.*,Wu Y.*(2019) Matrix sieving-enforced retrograde transcytosis regulates tissue accumulation of C-reactive protein.Cardiovascular Research, 115(2): 440-452.
13. Zhang L., Li H.-Y., Li W., Shen Z.-Y., Wang Y.-D., Ji S.-R.*,Wu Y.*(2018) An ELISA assay for quantifying monomeric C-reactive protein in plasma.Frontiers in Immunology, 9: 511.
14. Jia Z.-K., Li H.-Y., Liang Y.-L., Potempa L.A., Ji S.-R.*,Wu Y.*(2018) Monomeric C-reactive protein binds and neutralizes receptor activator of NF-κB ligand-induced osteoclast differentiation.Frontiers in Immunology, 9: 234.
15. Lv J.-M., Lv S.-Q., Liu Z.-P., Zhang J., Gao B.-X., Yao Z.-Y., Wu Y.-X., Potempa L.A., Ji S.-R.*, Long M.*,Wu Y.*(2018) Conformational folding and disulfide bonding drive distinct stages of protein structure formation.Scientific Reports, 8: 1494.
16. Li Q.-Y., Li H.-Y., Fu G., Yu F.*,Wu Y.*, Zhao M.-H. (2017) Autoantibodies against C-reactive protein influence complement activation and clinical course in lupus nephritis.Journal of the American Society of Nephrology, 28(10): 3044-3054.
17. Li H.-Y., Wang J., Meng F., Jia Z.-K., Su Y., Bai Q.-F., Lv L.-L., Ma F.-R., Potempa L.A., Ji S.-R.*,Wu Y.*(2016) An intrinsically disordered motif mediates diverse actions of monomeric C-reactive protein.Journal of Biological Chemistry, 291(16): 8795-8804.
18. Zhang L., Liu S.-H., Wright T.T., Shen Z.-Y., Li H.-Y., Zhu W., Potempa L.A., Ji S.-R.*, Szalai A.J.*,Wu Y.*(2015) C-reactive protein directly suppresses T helper 1 cell differentiation and alleviates experimental autoimmune encephalomyelitis.Journal of Immunology, 194(11): 5243-5252.
19. Li H.-Y., Wang J., Wu Y.-X., Zhang L., Liu Z.-P., Filep J.G., Potempa L.A.,Wu Y.*, Ji S.-R.* (2014) Topological localization of monomeric C-reactive protein determines pro-inflammatory endothelial cell responses.Journal of Biological Chemistry, 289(20): 14283-14290.
20. Wang M.-Y., Zhou H.-H., Zhang S.-C., Hui F., Zhu W., Su H.-X., Guo H.-Y., Li X.-W., Ji S.-R.*,Wu Y.*(2014) Recurrent mutations at C-reactive protein gene promoter SNP position -286 in human cancers.Cell Research, 24(4): 505-508.
21. Zhang Y.-J., Shi J.-M., Bai C.-J., Wang H., Li H.-Y.,Wu Y.*, Ji S.-R.* (2012) Intra-membrane oligomerization and extra-membrane oligomerization of amyloid-β peptide are competing processes as a result of distinct patterns of motif interplay.Journal of Biological Chemistry, 287(1): 748-756.
22. Wang M.-Y., Ji S.-R., Bai C.-J., El Kebir D., Li H.-Y., Shi J.-M., Zhu W., Costantino S., Zhou H.-H., Potempa L.A., Zhao J., Filep J.G.*,Wu Y.*(2011) A redox switch in C-reactive protein modulates activation of endothelial cells.FASEB Journal, 25(9): 3186-3196.
23. Zhu L., Chen L., Zhou X.-M., Zhang Y.-Y., Zhang Y.-J., Zhao J., Ji S.-R., Wu J.-W.*,Wu Y.*(2011) Structural insights into the architecture and allostery of full-length AMP-activated protein kinase.Structure, 19(4): 515-522.
24. Ji S.-R., Ma L., Bai C.-J., Shi J.-M., Li H.-Y., Filep J.G., Potempa L.A., Zhao J.,Wu Y.*(2009) Monomeric C-reactive protein activates endothelial cells via interaction with lipid raft micro-domains.FASEB Journal, 23(6): 1806-1816.
25. Ji S.-R.,Wu Y.*, Zhu L., Potempa L.A., Sheng F.-L., Lu W., Zhao J. (2007) Cell membranes and liposomes dissociate C-reactive protein (CRP) to form a new, biologically active structural intermediate: mCRPm.FASEB Journal, 21(1): 284-294.
26. Ji S.-R.,Wu Y.*, Potempa L.A., Liang Y.-H., Zhao J. (2006) Effect of modified C-reactive protein on complement activation: A possible complement regulatory role of mCRP in atherosclerotic lesions.Arteriosclerosis Thrombosis and Vascular Biology, 26(4): 935-941.
27. Ji S.-R.,Wu Y.*, Potempa L.A., Qiu Q., Zhao J. (2006) Interactions of C-reactive protein with low density lipoproteins: implications of an active role of modified C-reactive protein in atherosclerosis.International Journal of Biochemistry & Cell Biology, 384(4): 648-661.
28.Wu Y., He Y., Bai J., Ji S.-R., Tucker W.C., Chapman E.R.*, Sui S.-F.* (2003) Visualization of synaptotagmin I oligomers assembled on lipid monolayers.Proceedings of the National Academy of Sciences of the United States of America, 100(4): 2082-2087.
29. Ji S.-R.,Wu Y., Sui S.-F.* (2002) Cholesterol is an important factor affecting the membrane insertion of beta-amyloid peptide (ABeta 1-40), which may potentially inhibit the fibril formation.Journal of Biological Chemistry, 277(8): 6273-6279.
30.Wu Y., Ji S.-R., Wang H.-W., Sui S.-F.* (2002) Study of the spontaneous dissociation of rabbit C-reactive protein.Biochemistry (Moscow), 67(12): 1377-1382.
联系方式：
wuyi_med@xjtu.edu.cn
