2021年10月至今，西安交通大学第一附属医院，特聘教授。
【研究方向】
（1）肿瘤细胞胱氨酸代谢与铁死亡调控机制及其应用。发现抑癌基因BAP1通过表观调控基因表达促进胱氨酸依赖和铁死亡抑制肿瘤（2018，第一作者，Nature Cell Biology；2019,第一作者， Cell Cycle; 2024,通讯，Oncogenesis）；揭示胱氨酸代谢调控GPX4翻译表达新机制，证明胱氨酸依赖和铁死亡增敏肿瘤放、化疗的重要作用(2024, Journal of Advanced Research,末位通讯； 2020,共同第一作者, Cell Research; 2021,第一作者， Nature Communications; 2021, 共同通讯，Redox Biology；2025，末位通讯，Journal of Advanced Research)。
（2）肿瘤细胞葡萄糖依赖与双硫死亡的调控机制。揭示胱氨酸转运蛋白SLC7A11调控葡萄糖依赖的关键作用，阐明胱氨酸代谢促进葡萄糖依赖的分子机制，发现葡萄糖依赖调控双硫死亡的机理（2017,共一和通讯 Journal of Biological Chemistry; 2020，共一，Nature Cell Biology; 2023,第二作者，Nature Cell Biology）。发现内质网应激在葡萄糖缺乏诱导细胞死亡中的关键作用，揭示靶向内质网应激调控双硫死亡的分子机制（2020, 第一作者，Cancer Research; 2024,末位通讯, Advanced Science）。
【发表论文】
2025
Emmanuel N, He Q, Kang Y, Gao M, Wang M, Fan K, Xiong J, Wu S, Fa B, Xiao Z, Niu Y, Kang Y, Zhang D, Yao Y, Zhang Y. Hydrophobicity causes anomalous migration of cystine/glutamate antiporter SLC7A11 in SDS-PAGE with Low Acrylamide Concentration. FEBS Open Bio. 2025 Accepted.
Wang B, Huang C, Liu X, Liu Z, Zhang Y, Zhao W, Xu Q, Ho PC, Xiao Z. iMetAct: An integrated systematic inference of metabolic activity for dissecting tumor metabolic preference and tumor-immune microenvironment. Cell Rep. 2025 Mar 6;44(3):115375. doi: 10.1016/j.celrep.2025.115375. Epub ahead of print. PMID: 40053454.
Mao X, Xiong J, Cai M, Wang C, He Q, Wang B, Chen J, Xiao Z, Wang B, Han S, Zhang Y. SCARB1 links cholesterol metabolism-mediated ferroptosis inhibition to radioresistance in tumor cells. J Adv Res. 2025 Jan 18:S2090-1232(25)00045-1. doi: 10.1016/j.jare.2025.01.026. Epub ahead of print. PMID: 39832721
2024
Wang J, Chen J, Fan K, Wang M, Gao M, Ren Y, Wu S, He Q, Tu K, Xu Q, Zhang Y. Inhibition of Endoplasmic Reticulum Stress Cooperates with SLC7A11 to Promote Disulfidptosis and Suppress Tumor Growth upon Glucose Limitation. Adv Sci (Weinh). 2024 Dec 30:e2408789. doi: 10.1002/advs.202408789. Epub ahead of print. PMID: 39739602.
Wang J, Wang M, Wu S, Zhu Y, Fan K, Chen Y, Xiao Z, Chen J, Tu K, Huang D, Zhang Y, Xu Q. Tumor suppressor BAP1 suppresses disulfidptosis through the regulation of SLC7A11 and NADPH levels. Oncogenesis. 2024 Sep 12;13(1):31. doi: 10.1038/s41389-024-00535-0. PMID: 39266549; PMCID: PMC11393423.
Wu S, Wang J, Wang M, Zhou K, Huang D, Zhang Y, Zhang H. Glucose deprivation-induced disulfidptosis in human nucleus pulposus cells: a novel pathological mechanism of intervertebral disc degeneration. Biol Direct. 2024 Sep 12;19(1):81. doi: 10.1186/s13062-024-00528-4. PMID: 39267140; PMCID: PMC11396215.
Liu Z, Fan K, Abudukeremu A, Gao M, Tan X, Mao X, Li X, Ma W, Ma X, Li C, Yang Y, Tu K, Chen J, Zhang Y, Guan Y. LIMA1 links the E3 ubiquitin ligase RNF40 to lipid metabolism. Cell Death Discov. 2024 Jun 22;10(1):298. doi: 10.1038/s41420-024-02072-6. PubMed PMID: 38909032; PubMed Central PMCID: PMC11193757.
Mo H, Li R, Yang N, Han J, Xiao X, Zhang Y, Xiao Z, Jiao L, Xu Q, Tu K. USP40 promotes hepatocellular carcinoma progression through a YAP/USP40 positive feedback loop. Cancer Lett. 2024 May 1;589:216832. doi: 10.1016/j.canlet.2024.216832. Epub 2024 Mar 26. PubMed PMID: 38537774.
2023
Huang S, Zhang Q, Zhao M, Wang X, Zhang Y, Gan B, Zhang P. The deubiquitinase ZRANB1 is an E3 ubiquitin ligase for SLC7A11 and regulates ferroptotic resistance. J Cell Biol. 2023 Nov 6;222(11). doi: 10.1083/jcb.202212072. Epub 2023 Oct 13. PubMed PMID: 37831441; PubMed Central PMCID: PMC10570852.
Wang J, Wang H, Gao M, Zhang Y, Zhang L, Huang D, Tu K, Xu Q. The regulation of amino acid metabolism in tumor cell death: from the perspective of physiological functions. Apoptosis. 2023 Oct;28(9-10):1304-1314. doi: 10.1007/s10495-023-01875-9. Epub 2023 Jul 31. Review. PubMed PMID: 37523039.
Guo T, Yan W, Cui X, Liu N, Wei X, Sun Y, Fan K, Liu J, Zhu Y, Wang Z, Zhang Y, Chen L. Liraglutide attenuates type 2 diabetes mellitus-associated non-alcoholic fatty liver disease by activating AMPK/ACC signaling and inhibiting ferroptosis. Mol Med. 2023 Sep 28;29(1):132. doi: 10.1186/s10020-023-00721-7. PubMed PMID: 37770820; PubMed Central PMCID: PMC10540362.
Guo L, Zhang W, Zhang X, Wang J, Nie J, Jin X, Ma Y, Wang S, Zhou X, Zhang Y, Xu Y, Tanaka Y, Yuan J, Liao XH, Gong Y, Su L. A novel transcription factor SIPA1: identification and verification in triple-negative breast cancer. Oncogene. 2023 Aug;42(35):2641-2654. doi: 10.1038/s41388-023-02787-3. Epub 2023 Jul 27. PubMed PMID: 37500797; PubMed Central PMCID: PMC10457189.
Zeng F, Ye L, Zhou Q, He Y, Zhang Y, Deng G, Chen X, Liu H. Inhibiting SCD expression by IGF1R during lorlatinib therapy sensitizes melanoma to ferroptosis. Redox Biol. 2023 May;61:102653. doi: 10.1016/j.redox.2023.102653. Epub 2023 Mar 1. PubMed PMID: 36889082; PubMed Central PMCID: PMC10009726.
Liu X, Nie L, Zhang Y, Yan Y, Wang C, Colic M, Olszewski K, Horbath A, Chen X, Lei G, Mao C, Wu S, Zhuang L, Poyurovsky MV, James You M, Hart T, Billadeau DD, Chen J, Gan B. Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis. Nat Cell Biol. 2023 Mar;25(3):404-414. doi: 10.1038/s41556-023-01091-2. Epub 2023 Feb 6. PubMed PMID: 36747082; PubMed Central PMCID: PMC10027392.
2022
Emmanuel N, Li H, Chen J, Zhang Y. FSP1, a novel KEAP1/NRF2 target gene regulating ferroptosis and radioresistance in lung cancers. Oncotarget. 2022 Oct 19;13:1136-1139. doi: 10.18632/oncotarget.28301. PubMed PMID: 36264074; PubMed Central PMCID: PMC9584440.
Gao M, Fan K, Chen Y, Zhang G, Chen J, Zhang Y. Understanding the mechanistic regulation of ferroptosis in cancer: the gene matters. J Genet Genomics. 2022 Oct;49(10):913-926. doi: 10.1016/j.jgg.2022.06.002. Epub 2022 Jun 10. Review. PubMed PMID: 35697272.
Koppula P, Lei G, Zhang Y, Yan Y, Mao C, Kondiparthi L, Shi J, Liu X, Horbath A, Das M, Li W, Poyurovsky MV, Olszewski K, Gan B. A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers. Nat Commun. 2022 Apr 22;13(1):2206. doi: 10.1038/s41467-022-29905-1. PubMed PMID: 35459868; PubMed Central PMCID: PMC9033817.
Feng L, Weng J, Yao C, Wang R, Wang N, Zhang Y, Tanaka Y, Su L. Extracellular Vesicles Derived from SIPA1(high) Breast Cancer Cells Enhance Macrophage Infiltration and Cancer Metastasis through Myosin-9. Biology (Basel). 2022 Mar 31;11(4). doi: 10.3390/biology11040543. PubMed PMID: 35453742; PubMed Central PMCID: PMC9032110.
Fan K, Liu Z, Gao M, Tu K, Xu Q, Zhang Y. Targeting Nutrient Dependency in Cancer Treatment. Front Oncol. 2022;12:820173. doi: 10.3389/fonc.2022.820173. eCollection 2022. Review. PubMed PMID: 35178349; PubMed Central PMCID: PMC8846368.
更多相关发表文献，请点击下面链接：
https://www.ncbi.nlm.nih.gov/myncbi/yilei.zhang.1/bibliography/public/
https://orcid.org/0000-0003-1407-0301
欢迎有志于从事肿瘤代谢、表观调控、细胞死亡和靶向治疗等方向科学研究工作的研究生和博士后加入！
请发送个人简历和意向至邮箱zhangyilei@xjtu.edu.cn
