个人简介
吴昊，特聘研究员，博士生导师，2020年入选西安交通大学“青年拔尖人才B类计划”。研究领域为响应性纳米递送系统、核磁/荧光探针。目前已在Advanced Materials, Advanced Functional Materials,Nature Communication, Theranostics, Adv. Healthc. Mater.等杂志发表SCI论文28篇，其中一作或通讯论文11篇。担任Biomaterials, Theranostics, J. Phys. Chem., Acta Biomater., Colloid. Surface. B等国际期刊审稿人。
研究领域
本实验室专注于新型响应性纳米递送系统与递送动力学过程研究，通过多学科交叉与融合，联合应用固相合成、分子影像、纳米医学等技术手段，致力于基于响应性纳米递送策略的疾病诊疗及机制研究。主要研究方向有：
1.响应性纳米材料；
2.新型核磁、荧光诊断探针；
工作简历
2016年7月毕业于中国科学院大连化学物理研究所，获得博士学位，师从马小军研究员、谭明乾教授；2016年8月至2020年7月在加州大学戴维斯李源培教授研究团队从事博士后研究；2020年8月加入西安交通大学基础医学院，担任特聘研究员，博士生导师，入选西安交通大学“青年拔尖人才B类计划”。
科研项目
主持项目：
西安交通大学青年拔尖人才支持计划2020.8.1-2026.7.31；
参与项目：
NICHD，SBIR Phase II，Extremely long tumor retention, on-demand releasing Nano-Taxel for eradicating ovarian cancers，2019.9-2020.8，50.3万美金，已结，参加
NICHD，SBIR Phase I，Extremely long tumor retention, on-demand releasing Nano-Taxel for eradicating ovarian cancers，2018.9-2019.8，29.2万美金，已结，参加
NICHD，SBIR Phase I，Ninja Theranostics for overcoming the drug delivery barriers to pediatric brain tumor，2018.9-2019.6，22.5万美金，已结，参加
NIH，RO1，Smart targeting nano-theranostics for image-guided drug delivery to pediatric brain tumors，2015.12-2020.11，32.5万美金，已结，参加
NIH，RO1，Stimuli-responsive crosslinked theranostics against advanced prostate cancer，2015.9-2020.8，35.9万美金，已结，参加
国家自然科学基金委员会，国家重大科学仪器设备开发专项项目子课题，基于磁共振弛豫分析技术的小动物成分分析评价方法开发，2013.10-2018.9，74.2万元，已结，参加
国家自然科学基金委员会，国家自然科学基金委重大研究计划项目基金子课题，肿瘤靶向MRI/NIR双模态自组装标记物的构建及基于新型粗粒化分子模型的理论探索，2013.1-2015.12，75万元，已结，参加
科研论文
1. Hao Wu, Hongwei Lu, Wenwu Xiao, Jinfan Yang, Hongxu Du, Yingbin Shen, Haijing Qu, Bei Jia, Suman K Manna, Mythili Ramachandran, Xiangdong Xue, Zhao Ma, Xiaobao Xu, Zhongling Wang, Yixuan He, Kit S. Lam, Robert J. Zawadzki, Yuanpei Li* and Tzu-Yin Lin*. Sequential Targeting in Crosslinking Nano-theranostics for Tackling the Multi-barriers of Brain Tumors. Adv.Mater., 2020, 1903759.
2. Hao Wu§, Lu Zhang§, Jinfan Yang, Ruonan Bo, Lin Kai, Dalin Zhang, Hongxu Du, Mythili Ramachandran, Yingbin Shen, Yangxi Xu, Xiangdong Xue, Zhao Ma, Tzu-Yin Lin and Yuanpei Li*. Rotatable Aggregation-Induced-Emission / Aggregation-Caused-Quenching Ratio Strategy for Real-Time Tracking Nanoparticle Delivery Dynamics, Adv. Funct. Mater. 2020, 1910348.
3. Hao Wu§, Huihui Wang§, Han Liao, Yan Lv, Xiaojie Song, Xiaojun Ma and Mingqian Tan*. Multifunctional Nanostructures for Tumor Targeted Molecular Imaging and Photodynamic Therapy. Adv.Healthc.Mater., 2016, 5, 311–318
4. Jinfan Yang*, Zhifeng Ao, Hao Wu*, Sufeng Zhang. Immobilization of chitosan-templated MnO2 nanoparticles onto filter paper by redox method as a retrievable Fenton-like dip catalyst. Chemosphere. 2021, 268, 128835
5. Hao Wu§, Haidong Zhao§, Xiaojie Song, Shen Li, Xiaojun Ma* and Mingqian Tan*. Self-assembly- induced near-infrared fluorescent nanoprobes for effective tumor molecular imaging, J. Mater. Chem. B., 2014, 2, 5302–5308
6. Jinfan Yang*, Zhifeng Ao, Hao Wu*, Sufeng Zhang, Concong Chi, Chen Hou, Liwei Qian. Waste paper-derived magnetic carbon composite: A novel eco-friendly solid acid for the synthesis of n-butyl levulinate from furfuryl alcohol. Renew. Energ., 2020, 146, 477-483.
7. Jinfan Yang*, Xiaoru Niu, Hao Wu*, Hongyu Zhang, Zhifeng Ao, Sufeng Zhang. Valorization of humin as a glucose derivative to fabricate a porous carbon catalyst for esterification and hydroxyalkylation/alkylation. Waste Manage., 2020, 103, 407-415.
8. Hao Wu, Ying Ma, Shuang Shan, Mingqian Tan* and Xiaojun Ma*. Separable cells co-culture method by microcapsules loading cells. Chinese Journal of Cell Biology, 2013, 35(5):697-702.
9. Yan Luo§, Hao Wu§, Caihong Feng, Kai Xiao, Xixiao Yang, Qiangqiang Liu, Tzu-yin Lin, Hongyong Zhang, Jeffrey H. Walton, Yousif Ajena, Yide Hu, Kit S. Lam* and Yuanpei Li*. “One-Pot” Fabrication of Highly Versatile and Biocompatible Poly(vinyl alcohol)-porphyrin-based Nanotheranostics. Theranostics, 2017, 7 (16) 3901-3914
10. Xue-Xiang Zhang§, Hao Wu§, Peng Li, Zong-Jin Qu, Ming-Qian Tan and Ke-Li Han*. A versatile two-photon fluorescent probe for ratiometric imaging E. coli β-galactosidase in live cells and in vivo, Chem. Commun., 2016, 52, 8283-8286.
11. Huihui Wang§, Hao Wu§, Hujun Shen, Shaote Geng, Beibei Wang, Yanfang Wang, Xiaojun Ma, Guohui Li and Mingqian Tan*. A bimodal MRI and NIR liposome nanoprobe for tumor targeted molecular imaging. J. Mater. Chem. B., 2015, 3, 8832-8841.
12. Zheyu Shen, Hao Wu, Sugeun Yang, Xuehua Ma, Zihou Li, Mingqian Tan* and Aiguo Wu*. A novel Trojan-horse targeting strategy to reduce the non-specific uptake of nanocarriers by non-cancerous cells, Biomaterials, 2015,70, 1-11.
13. Xiaojie Song, Hao Wu, Shen Li,Yanfang Wang, Xiaojun Ma* and Mingqian Tan*. Ultrasmall Chitosan-genipin Nanocarriers Fabricated from Reverse Microemulsion Process for Tumor Photothermal Therapy in Mice. Biomacromolecules, 2015, 16, 2080−2090.
14. Chengkun Jiang, Hao Wu, Xiaojie Song, Xiaojun Ma, Jihui Wang and Mingqian Tan*. Presence of photoluminescent carbondots in Nescafe original instant coffee: Applications to bioimaging. Talanta, 2014,127, 68–74.
15. Xiangdong Xue, Yee Huang, Ruonan Bo, Bei Jia, Hao Wu, Ye Yuan, Zhongling Wang, Zhao Ma, Di Jing, Xiaobao Xu, Weimin Yu, Tzu-yin Lin & Yuanpei Li*. Trojan Horse nanotheranostics with dual transformability and multifunctionality for highly effective cancer treatment, Nat. Commun., 2018, 9, 3653.
16. Zhongling Wang, Xiangdong Xue, Yixuan He, Ziwei Lu, Bei Jia, Hao Wu, Ye Yuan, Yee Huang, Han Wang, Hongwei Lu, Kit S Lam, Tzu‐Yin Lin, Yuanpei Li*. Novel Redox‐Responsive Polymeric Magnetosomes with Tunable Magnetic Resonance Property for In Vivo Drug Release Visualization and Dual‐Modal Cancer Therapy, Adv. Funct. Mater., 2018, 28, 1802159.
17. Yan Lv, Jianbin Zhang, Hao Wu, Shan Zhao, Yizhe Song, Shujun Wang, Bing Wang, Guojun Lv* and Xiaojun Ma*. A Protease Inhibition Strategy Based on Acceleration of Autolysis. Chem. Commun. (IF: 5.996), 2015 Apr 7;51(27):5959.
18. Nirun Jatupaiboon, Yanfang Wang, Hao Wu, Xiaojie Song, Yizhe Song, Jianbin Zhang, Xiaojun Ma* and Mingqian Tan*. A facile microemulsion template route for producing hollow silica nanospheres as imaging agents and drug nanocarriers. J. Mater. Chem. B., 2015,3, 3130-3133.
19. Mingqian Tan*, Xintong Li, Hao Wu, Beibei Wang, Jing Wu. N-doped carbon dots derived from bovine serum albumin and formic acid with one- and two-photon fluorescence for live cell nuclear imaging. Colloids. Surface. B, 2015, 136, 141–149.
20. Huizhen Zheng, Hongguo Xie, Hao Wu, Feng Wang, Xiudong Liu*, Weiting Yu* and Xiaojun Ma. Investigation of spherical hydrogel surface with optical interferometer. Colloid Surface A, 2015,484, 457-462.
21. Zhiqiang Ye, Rong Tang, Hao Wu, Beibei Wang, Mingqian Tan* and Jingli Yuan. Preparation of europium complex-conjugated carbon dots for ratiometric fluorescence detection of copper(II) ions, New J. Chem., 2014, 38 (12), 5721-5726.
22. Beibei Wang, Yanfang Wang, Hao Wu, Xiaojie Song,Xin Guo, Demeng Zhang, Xiaojun Ma* and Mingqian Tan*. A mitochondria-targeted fluorescent probe based on TPP-conjugated carbon dots for both one- and two-photon fluorescence cell imaging. RSC Adv., 2014, 4, 49960-49963.
23. Han Liao, Ziyi Wang, Song Chen, Hao Wu, Xiaojun Ma and Mingqian Tan*. One-pot synthesis of gadolinium (iii) doped carbon dots for fluorescence/magnetic resonance bimodal imaging. RSC Adv., 2015,5(82), 66575-66581.
24. Chang Liu, Yang Liu, Xiaoxi Xu, Hao Wu, Hongguo Xie, Li Chen, Ting Lu, Li Yang, Xin Guo, Guangwei Sun*. Potential effect of matrix stiffness on the enrichment of tumor initiating cells under three-dimensional culture conditions. Experimental cell research, 2015, 1, 123-134.
25. Beibei Wang, Shujun Wang, Yanfang Wang, Yan Lv, Hao Wu, Xiaojun Ma* and Mingqian Tan*. Highly fluorescent carbon dots for visible sensing of doxorubicin release based on efficient nanosurface energy transfer. Biotechnology Letters, 2015.
26. Yan Yang, Xiaojie Song, Yi Yao, Hao Wu, Jian Liu, Yaopeng Zhao, Mingqian Tan* and Qihua Yang*. Ultrasmall single micelle@ resin core–shell nanocarriers as efficient cargo loading vehicles for in vivo biomedical applications. J. Mater. Chem. B, 2015, 3, 4671-4678.
27. Mingqian Tan, Lingxin Zhang, Rong Tang, Xiaojie Song, Yimin Li, Hao Wu, Yangfang Wang, Guojun Lv, Wangfa Liu and Xiaojun Ma*. Enhanced photoluminescence and characterization of multicolor carbon dots using plant soot as a carbon source. Talanta , 2013, 115, 950-956.
28. Yang Liu, ShujunWang, Dongsheng Sun, Yongdong Liu, Yang Liu, YangWang, Chang Liu, Hao Wu, Yan Lv, Ying Ren, XinGuo, Guangwei Sun* and Xiaojun Ma*. Development of a Biomimetic Chondroitin Sulfate-modified Hydrogel to Enhance the Metastasis of Tumor Cells. Sci. Rep., 2016 Jul 19; 6:29858.
联系方式
电子邮箱：lfshwu@xjtu.edu.cn
联系地址：西安交通大学创新港21号楼4102
