个人简介

王福，西安交通大学医学部基础医学院教授、博导，青年拔尖人才A类，福建省“闽江学者”讲座教授，Frontiers in Oncology杂志副主编。主要研究方向为生物医学影像及肿瘤诊疗。先后主持包括国家自然科学基金（面上项目、青年项目）、国家“973计划”二级子课题、陕西省自然科学基金面上项目、陕西省留学人员科技活动择优资助项目（优秀类，2项）等10余个基金项目；近年来在PNAS、Nature Protocols、Nucleic Acids Research、Molecular Therapy、Oncogene、Cancer Letters等国际主流期刊发表SCI论文40余篇；申请/授权中国发明专利10余项；研究成果以第一完成人获得陕西省高等学校科学技术奖一等奖以及陕西省科学技术奖三等奖等奖项。

研究领域方向

本实验室专注于肿瘤分子影像与精准治疗研究领域，通过多学科交叉与融合，联合应用分子影像、合成生物学、分子细胞生物学、基因工程、纳米医学等技术手段，致力于基于分子成像的恶性肿瘤诊疗及分子机制研究。主要研究方向有：

1、合成基因线路设计及成像

2、报告基因探针开发及生物医学应用

3、核酸生物学

4、生物医学成像

代表性论文

1. Ji M, Wang X, Zheng H, Mao W, Shi X, Chen S, Tang C,Wang F*. A secreted reporter for blood monitoring of pyroptotic cell death.Analytical Chemistry, 2020, 92, 15565-15572.

2. Liu W, Liu Q, Zhang B, Lin Z, Li X, Yang X, Pu M, Zou R, He Z*,Wang F*, Dou K*. The mRNA of TCTP functions as a sponge to maintain homeostasis of TCTP protein levels in hepatocellular carcinoma.Cell Death & Disease. 2020, 11:974

3. Mao W, Hu C, Zheng H, Xie J, Shi X, Du Y, Wang F*.A functionalized polydopamine theranostic nanoprobe for efficient imaging of miRNA-21 and in vivo synergetic cancer therapy. Molecular Therapy - Nucleic Acids. 2020, 22:27-37

4. Song Y, Xu Z, Wang F*. Genetically encoded reporter genes for microRNA imaging in living cells and animals. Molecular Therapy - Nucleic Acids.2020, 21:555-567

5. Zheng H, Chen S, Wang X, Xie J, Tian J*, Wang F*. Intron retained bioluminescence reporter for real-time imaging of pre-mRNA splicing in living subjects. Analytical Chemistry. 2019,91(19): 12392-12398

6. Zhang B, Wang X, Deng J, Zheng H, Liu W, Chen S, Tian J*, Wang F*. p53-dependent upregulation of miR-16-2 by sanguinarine induces cell cycle arrest and apoptosis in hepatocellular carcinoma, Cancer Letters, 2019, 459:50-58

7. Chen G*, Chen J, Qiao Y, Shi Y, Liu W, Zeng Q, Xie H, Shi X, Sun Y, Liu X, Li T, Zhou L, Wan J, Wang H*, Wang F*. ZNF830 mediates cancer chemoresistance through promoting homologous-recombination repair. Nucleic Acids Research, 2018, 46(3): 1266-1279

8. Li Z, Wang B, Zhang Z, Wang B, Xu Q, Mao W, Tian J, Yang K*, Wang F*. Radionuclide imaging-guided chemo-radioisotope synergistic therapy using I-131 labeled polydopamine multifunctional nanocarrier. Molecular Therapy. 2018, 26(5):1385-1393

9. Zheng H, Zhou L, Shi Y, Tian J*, Wang F*. Tyrosinase-based reporter gene for photoacoustic imaging of microRNA-9 regulated by DNA methylation in living subjects. Molecular Therapy - Nucleic Acids. 2018, 11: 34-40.

10. Liu W, Zhang B, Chen G, Wu W, Zhou L, Shi Y, Zeng Q, Li Y, Sun Y, Deng X*, Wang F*. Targeting miR-21 with sophocarpine inhibits tumor progression and reverses epithelial-mesenchymal transition in head and neck cancer. Molecular Therapy, 2017, 25(9):2129-2139

11. Chen G*, Zhang B, Xu H, Sun Y, Shi Y, Luo Y, Jia H, Wang F*, Suppression of Sirt1 sensitizes lung cancer cells to WEE1 inhibitor MK-1775-induced DNA damage and apoptosis. Oncogene, 2017, 36(50):6863-6872.

12. Wang F*, Yang K, Wang Z, Ma Y, Gutkind JS, Hida N, Niu G, Tian J*. Combined image guided monitoring the pharmacokinetics of rapamycin loaded human serum albumin nanoparticles with a split luciferase reporter. Nanoscale. 2016, 8(7): 3991-4000

13. Wang F*, Zhang B, Zhou L, Shi Y, Li Z, Xia Y, Tian J*. Imaging dendrimer-grafted graphene oxide mediated anti-miR-21 delivery with an activatable luciferase reporter. ACS Applied Materials & Interfaces. 2016, 8(14):9014-21.

14. Wang Z#, Wang F#, Hida N, Kiesewetter DO, Tian J, Niu G*, Chen X*. Design of a functional cyclic HSV1-TK reporter and its application to PET imaging of apoptosis. Nature Protocols. 2015, 10(5):807-821

15. Wang F#, Wang Z#, Hida N, Kiesewetter DO, Ma Y, Yang K, Rong P, Liang J, Tian J*, Niu G*, Chen X*. A cyclic HSV1-TK reporter for real-time PET imaging of apoptosis. PNAS. 2014, 111(14): 5165-70.

联系方式

电子邮箱：wangfu@xjtu.edu.cn

联系地址：西安交通大学基础医学院

个人主页：http://gr.xjtu.edu.cn/web/wangfu