陈乔依，研究员/博士研究生导师
西安交通大学医学部
基础医学院细胞生物学与遗传学系
遗传与发育研究所
西安交通大学第一附属医院客座教授
2019年于美国纽约大学获博士学位，获评国家优秀自费留学生、美国国立卫生研究院等奖学金；同年留校担任纽约大学医学院Research Scientist；2020年入选西安交通大学“青年拔尖”人才计划。课题组在Cancer Letters、Cell Death & Disease、Annual Reviews of Pharmacology & Toxicology、Environmental Pollution、Journal of Global Health等国际权威学术期刊共发表论文40余篇（高被引论文2篇）h-index20，累计被引用1500余次。截至目前，主持国家自然科学基金、陕西省自然科学基金、西安交通大学医学“基础-临床”融合创新项目、西安交通大学“青年拔尖人才计划”基金项目等课题。
研究生招生信息：细胞生物学（71009）和遗传学（71007）
工作经历：
2020至 今， 西安交通大学，医学部 基础医学院，研究员/博导
2019至2020， 美国纽约大学，Research Scientist
教育经历：
2014至2019， 美国纽约大学，博士, Kirschstein NRSA (NIH)奖学金
2010至2014， 美国堪萨斯大学，学士
研究领域：分子癌症学、表观遗传学、环境医学
研究方向：课题组主要研究方向为癌症发生发展的表观遗传机制，其中包括组蛋白变体、染色质结构、外泌体信号通路、非编码RNA在DNA复制、基因转录、基因组稳定性维持等过程中发挥的重要作用。
部分科研论文：
1.Wu J, Wen T, Marzio A, Song D, Chen S, Yang C, Zhao F, Zhang B, Zhao G, Ferri A, Cheng H, Ma J, Ren H,Chen QY#, Yang Y#, Qin S#. FBXO32-mediated degradation of PTEN promotes lung adenocarcinoma progression. Cell Death Dis. 2024.https://pubmed.ncbi.nlm.nih.gov/38643215/（#Corresponding author）
2.Tong D, Zhou J, Zhou J, Wang X, Gao B, Rui X, Liu L,Chen QY#, Huang C#. LAMC2 mitigates ER stress by enhancing ER-mitochondria interaction via binding to MYH9 and MYH10. Cancer Gene Ther. 2024.https://pubmed.ncbi.nlm.nih.gov/37891404/（#Corresponding author）
3.Liu J,Chen QY#. Sequential link in depression, sleep and cognition: Longitudinal evidence from a serial multiple mediation analysis of older adults in China. Arch Gerontol Geriatr. 2024.https://pubmed.ncbi.nlm.nih.gov/37952418/（#Corresponding author）
4.Tong D, Wang X, Liu L, Wen T,Chen QY#, Huang C#. LAMC2 promotes EGFR cell membrane localization and acts as a novel biomarker for tyrosine kinase inhibitors (TKIs) sensitivity in lung cancer. Cancer Gene Ther. 2023.https://pubmed.ncbi.nlm.nih.gov/37542131/（#Corresponding author）
5.Chen QY, Gao B, Tong D, Huang C. Crosstalk between extracellular vesicles and tumor-associated macrophage in the tumor microenvironment. Cancer Lett. 2023.https://pubmed.ncbi.nlm.nih.gov/36306939/
6.Song Q, Gao Q, Chen T, Wen T, Wu P, Luo X,Chen QY#. FAM3A Ameliorates Brain Impairment Induced by Hypoxia-Ischemia in Neonatal Rat. Cell Mol Neurobiol. 2023.https://pubmed.ncbi.nlm.nih.gov/34853925/（#Corresponding author）
7.Liu J, Qiang F, Dang J,Chen QY#. Depressive Symptoms as Mediator on the Link between Physical Activity and Cognitive Function: Longitudinal Evidence from Older Adults in China. Clin Gerontol. 2023.https://pubmed.ncbi.nlm.nih.gov/35603686/（#Corresponding author）
8.Chen QY,Wu P, Wen T, Qin X, Zhang R, Jia R, Jin J, Hu F, Xie X, Dang J. Association of cerebral spinal fluid copper imbalance in amyotrophic lateral sclerosis. Front Aging Neurosci. 2022.https://pubmed.ncbi.nlm.nih.gov/36466599/
9.Wen T,Chen QY#. Dynamic Activity of Histone H3-Specific Chaperone Complexes in Oncogenesis. Front Oncol. 2022.https://pubmed.ncbi.nlm.nih.gov/35087762/（#Corresponding author）
10.Qin X, Wu P, Wen T, Jia R, Zhang R, Jin J, Hu F,Chen QY#, Dang J#. Comparative assessment of blood Metal/metalloid levels, clinical heterogeneity, and disease severity in amyotrophic lateral sclerosis patients. Neurotoxicology. 2022.https://pubmed.ncbi.nlm.nih.gov/35007622/（#Corresponding author）
11.Qin X, Kang L, Liu X, Jin J, Hu F, Lu W, Deng Y,Chen QY, Dang J. Acute nitrous oxide-induced neuropathy mimicking Guillain-Barré syndrome. J Peripher Nerv Syst. 2022.https://pubmed.ncbi.nlm.nih.gov/35611446/
12.Liu J, Qiang F, Dang J,Chen QY#. Quantifying the parallel mediation influence of body mass index and depression on physical activity and cognitive function among 3,611 Chinese older adults. Front Aging Neurosci. 2022.https://pubmed.ncbi.nlm.nih.gov/36158538/（#Corresponding author）
13.Jia R,Chen QY, Zhou Q, Zhang R, Jin J, Hu F, Liu X, Qin X, Kang L, Zhao S, Dang Y, Dang J. Characteristics of serum metabolites in sporadic amyotrophic lateral sclerosis patients based on gas chromatography-mass spectrometry. Sci Rep. 2021.https://pubmed.ncbi.nlm.nih.gov/34675267/
14.Chen QY, Wen T, Wu P, Jia R, Zhang R, Dang J. Exosomal Proteins and miRNAs as Mediators of Amyotrophic Lateral Sclerosis. Front Cell Dev Biol. 2021.https://pubmed.ncbi.nlm.nih.gov/34568332/
15.Chen QY#, Xie X. Association of Exosomal miR-210 with Signaling Pathways Implicated in Lung Cancer. Genes. 2021.https://pubmed.ncbi.nlm.nih.gov/34440422/（#Corresponding author）
16.Zhu Y,Chen QY, Jordan A, Sun H, Roy N, Costa M. RUNX2/miR 31/SATB2 pathway in nickel induced BEAS 2B cell transformation. Oncol Rep. 2021.https://pubmed.ncbi.nlm.nih.gov/34109987/
17.Chen QY, Costa M. Arsenic: A Global Environmental Challenge. Annu Rev Pharmacol Toxicol. 2021.https://pubmed.ncbi.nlm.nih.gov/33411580/[ESI高被引论文]
18.Jin J, Hu F, Zhang Q,Chen QY, Li H, Qin X, Ji R, Kang L, Dang Y, Dang J. The degeneration of upper and lower motor neuron from the perspective of clinical neurological examination and MRI-electromyography manifold detection in amyotrophic lateral sclerosis. Neuroreport. 2021.https://pubmed.ncbi.nlm.nih.gov/33252476/
19.Liu J,Chen QY#, Dang J. Understanding risks of refractive error among Chinese children amidst pandemic disruptions: results from a rapid survey. BMC Ophthalmol. 2021.https://pubmed.ncbi.nlm.nih.gov/34663261/（#Corresponding author）
20.Liu J,Chen QY#, Dang J. Examining risk factors related to digital learning and social isolation: Youth visual acuity in COVID-19 pandemic. J Glob Health. 2021.https://pubmed.ncbi.nlm.nih.gov/34484707/（#Corresponding author）
21.Liu J, Li B, Sun Y,Chen QY#, Dang J. Adolescent Vision Health During the Outbreak of COVID-19: Association Between Digital Screen Use and Myopia Progression. Front Pediatr. 2021.https://pubmed.ncbi.nlm.nih.gov/34113588/（#Corresponding author）
22.Liu J, Li B,Chen QY#, Dang J. Student Health Implications of School Closures during the COVID-19 Pandemic: New Evidence on the Association of e-Learning, Outdoor Exercise, and Myopia. Healthcare. 2021.https://pubmed.ncbi.nlm.nih.gov/33922486/（#Corresponding author）
23.Chen QY, Shen S, Sun H, Wu F, Kluz T, Kibriya MG, Chen Y, Ahsan H, Costa M. PBMC gene expression profiles of female Bangladeshi adults chronically exposed to arsenic-contaminated drinking water. Environ Pollut. 2020.https://pubmed.ncbi.nlm.nih.gov/31918125/
24.Chen D*,Chen QY*, Wang Z*, Zhu Y, Kluz T, Tan W, Li J, Wu F, Fang L, Zhang X, He R, Shen S, Sun H, Zang C, Jin C, Costa M. Polyadenylation of Histone H3.1 mRNA Promotes Cell Transformation by Displacing H3.3 from Gene Regulatory Elements. iScience. 2020.https://pubmed.ncbi.nlm.nih.gov/32920490/（*Co-first author）
25.Chen QY, DesMarais T, Costa M. Metals and Mechanisms of Carcinogenesis. Annu Rev Pharmacol Toxicol. 2019.https://pubmed.ncbi.nlm.nih.gov/30625284/[ESI高被引论文]
26.Chen QY, Des Marais T, Costa M. Deregulation of SATB2 in carcinogenesis with emphasis on miRNA-mediated control. Carcinogenesis. 2019.https://pubmed.ncbi.nlm.nih.gov/30916759/
27.Chen QY*, Murphy A, Sun H, Costa M. Molecular and epigenetic mechanisms of Cr(VI)-induced carcinogenesis. Toxicol Appl Pharmacol. 2019.https://pubmed.ncbi.nlm.nih.gov/31228494/
28.Li J, Chen Y,Chen QY, Liu D, Xu L, Cheng G, Yang X, Guo Z, Zeng Y. Role of transient receptor potential cation channel subfamily V member 1 (TRPV1) on ozone-exacerbated allergic asthma in mice.Environ Pollut. 2019.https://pubmed.ncbi.nlm.nih.gov/30708321/
29.Jin J, Hu F, Zhang Q,Chen QY, Li H, Qin X, Jia R, Kang L, Dang Y, Dang J. Dominant Heterogeneity of Upper and Lower Motor Neuron Degeneration to Motor Manifestation of Involved Region in Amyotrophic Lateral Sclerosis. Sci Rep. 2019.https://pubmed.ncbi.nlm.nih.gov/31882886/
30.Hu F, Jin J,Chen QY, Kang L, Jia R, Qin X, Liu X, Dang Y, Dang J. Dissociated lower limb muscle involvement in amyotrophic lateral sclerosis and its differential diagnosis value. Sci Rep. 2019.https://pubmed.ncbi.nlm.nih.gov/31780761/
31.Chen QY, Costa M. PI3K/Akt/mTOR Signaling Pathway and the Biphasic Effect of Arsenic in Carcinogenesis. Mol Pharmacol. 2018.https://pubmed.ncbi.nlm.nih.gov/29769245/
32.Chen QY, Li J, Sun H, Wu F, Zhu Y, Kluz T, Jordan A, DesMarais T, Zhang X, Murphy A, Costa M. Role of miR-31 and SATB2 in arsenic-induced malignant BEAS-2B cell transformation. Mol Carcinog. 2018.https://pubmed.ncbi.nlm.nih.gov/29603397/
33.Chen QY, Costa M. Oncogenic and tumor suppressive roles of special AT-rich sequence-binding protein. J Carcinog. 2018.https://pubmed.ncbi.nlm.nih.gov/30123095/
34.Chen QY, Costa M. A comprehensive review of metal-induced cellular transformation studies. Toxicol Appl Pharmacol. 2017.https://pubmed.ncbi.nlm.nih.gov/28506836/
35.Chen QY, Costa M, Sun H. Structure and function of histone acetyltransferase MOF. AIMS Biophys. 2015.https://pubmed.ncbi.nlm.nih.gov/28503659/
联系方式
通信地址：西安交通大学基础医学院
西咸新区中国西部科技创新港
21号楼4-4048室
电子邮箱：qychen203@xjtu.edu.cn
个人主页：https://gr.xjtu.edu.cn/en/web/qychen203
