个人简介
杜宝吉，西安交通大学基础医学院/转化医学研究院研究员，博士生导师，生物物理系副主任，兼任国家生物安全证据基地研究员，西安交通大学第一附属医院和第二附属医院特聘教授。2017年，获得中国科学院大学博士学位（师从汪尔康院士和汪劲教授）；2017年至2020年，在康奈尔大学从事博士后研究工作；2020年，加入西安交通大学，获得学校“青年拔尖人才B类计划”支持。担任Journal of Analysis and Testing的青年编委，以通讯或第一作者在Nature Communications，Advanced Functional Materials, ACS Nano, Advanced Drug Delivery Reviews, Analytical Chemistry等杂志发表多篇论文，担任Advanced Materials、Advanced Functional Materials、ACS Nano等期刊审稿人。获得2018年吉林省自然科学学术成果二等奖一项（排名第一）。
研究领域
仿生纳米酶是一种兼具天然酶催化特性的活性物质，具备高稳定性、低成本以及易于修饰改造等诸多优势。然而，其在特异性、催化活性等方面仍存在诸多亟待深入探究的底层科学问题。与此同时，仿生纳米酶在传感检测以及生物医用材料的应用领域展现出巨大的转化潜力。本实验室致力于深入探索仿生纳米酶催化的分子机制以及活性调控等科学问题，并着力发展适配仿生纳米酶应用的水凝胶、气凝胶和宏观介质等载体，进而设计出高性能的传感器和生物医用材料。具体研究方向如下：
1. 仿生纳米酶多元活性调控与生物医学应用
2. 仿生纳米酶固相化设计与检测平台开发
3. 仿生纳米酶催化时序干预与先进应用
4. 仿生纳米酶在视觉健康领域的应用
科研项目
主持国家自然科学基金、中央高校基本科研业务费、横向课题等项目6项
代表性论文（通讯作者，近3年）
1. Yurong Chen, Yihao Liu, Bowen Ren, Huahua Liu, Yiming Ren, Sergio Martin-Saldaña, Ting Wang, Bochen An, Ye Zhu, Binhui Wang, Yiyang Zhao, Yining Gong, Wanglin Duan, Bin Zhu, Luyao Feng, Qingzu Liu, Jinqing Li, Baoji Du*, Jianheng Liu*, Yazhong Bu*, Nature Communications，2025，Accepted.
2. Weijuan Jia, Bin Zhu, Dongquan Xiang, Bo Zhang, Zhan Qu，Zhibing Hua, Lei Xiong, Yazhong Bu*, Baoji Du*, Jinpeng Jia*, Peroxidase Nanozyme-Incorporated Sponge: A Smartphone-Enabled Dual-Mode Visual Sensing Platform for Trace Uric Acid Detection via a Shape-Memory Effect-Driven Signal Amplification Strategy，Biosensors and Bioelectronics, 2025，283，117541.（IF：10.7）
3. Weijuan Jia, Bin Zhu, Aoxue Zhang, Haiwei Hou, Zhan Qu, Yazhong Bu*, Lan Liu*, Baoji Du*, Hydrophilic Shape-Memory Nanozyme Aerogel for the Development of a Reusable and Signal-Amplified Sensor, Advanced Functional Materials, 2025, doi:10.1002/adfm.202418910. （IF：18.5）
4. Yiyang Zhao, Wanglin Duan, Bin Zhu, Yurong Chen, Ye Zhu, Sergio Martin-Saldaña, Zhengtao Xiao, Xinyi Liu, Luyao Feng, Yiming Ren, Yining Gong, Fuquan Huo, Jinqing Li, Yazhong Bu*, Baoji Du*, Lining Zhang*, Nanozyme‐Engineered Hyaluronic Acid Adhesives Loading Platelet‐Rich Plasma for Multilayered Osteoarthritis Treatment with Pain‐Relief Effect, Advanced Functional Materials, 2025, 35，17，2418660. （IF：18.5）
5. Binhui Wang, Bin Zhu, Yihao Liu, Bowen Ren, Yurong Chen, Luyao Feng, Sergio Martin-Saldana, Bochen An, Yining Gong, Yiming Ren, Jinqing Li, Da Huang*, Baoji Du*, Jianheng Liu*, Yazhong Bu*, Fast Recoverable Shape Memory Cryogels Engineered with Surfactant‐Stabilized Bubbles and Vermiculite for Non‐Compressible Hemostasis, Advanced Functional Materials, 2025, 35，4，2414340. （IF：18.5）
6. Haiwei Hou, Weijuan Jia, Aoxue Zhang, Minyang Su, Yazhong Bu*, Lan Liu*, Baoji Du*, Unveiling generally-ignored co-substrate effect of catalase-inherent peroxidase mimic for self-verifiable detection of high-concentration hydrogen peroxide, Small Methods, 2025, 9，1，2400847. （IF：10.7）
7. Yining Gong, Bin Zhu, Yurong Chen, Furong Li, Wanglin Duan, Sergio Martin-Saldaña, Ruopei Yang, Xiangcheng Gao, Bo Zhang, Lei Luo, Zhengtao Xiao, Baoji Du*, Liang Yan*, Yazhong Bu*, Organism-Inspired Antioxidant Bioadhesive with Strong Sealing Ability to Prevent Epidural Adhesion, ACS Nano, 2024, 18, 32, 21411–21432. （IF：15.8）
8. Bo Zhang, Yining Gong, Lan Liu, Haiwei Hou, Xiangcheng Gao, Yazhong Bu*, Baoji Du*, Liang Yan*，Chitosan-stabilized Pt/Ru peroxidase nanozyme integrating with hydrogel as a visual sensor for “signal-on” alkaline phosphatase detection, ACS Applied Nano Materials, 2024, 7, 10, 11248-11257. （IF：5.9）
9. Xiangcheng Gao, Lan Liu, Haiwei Hou, Weijuan Jia, Aoxue Zhang, Bo Zhang, Yazhong Bu, Yining Gong*, Liang Yan*, Baoji Du*，Construct a magnetic Pt/Ru alloy peroxidase mimic as a reusable and cost-effective “signal-off” sensing platform for sensitive and wide-linear-range assay, Analytical Chemistry, 2024, 96, 25, 10467–10475. （IF：7.4）
10. Wanglin Duan, Xianzhen Jin, Yiyang Zhao, Sergio Martin-Saldaña, Shuaijun Li, Lina Qiao, Liang Shao, Bin Zhu, Shibo Hu, Furong Li, Luyao Feng, Yao Ma, Baoji Du*, Lining Zhang*, Yazhong Bu*, Engineering injectable hyaluronic acid-based adhesive hydrogels with anchored PRP to pattern the micro-environment to accelerate diabetic wound healing，Carbohydrate Polymers, 2024, 337, 122146. （IF：11.2）
11. Yang Gao, Xiangcheng Gao, Haiwei Hou, Zhan Qu, Hao Li*, Baoji Du*, Peifu Tang*, Stabilizer-free MnO2 nanozyme with singlet-oxygen conducted high oxidase-like activity and fast catalysis capability for improving alkaline phosphatase assay, Sensors and Actuators B: Chemical, 2024, 135280. （IF：8.4）
12. Haiwei Hou, Lan Liu*, Qiuyue Li, Jianming Wang*, Baoji Du*, A Cascade Enzyme System Integrating Peroxidase Mimic with Catalase for Linear Range Expansion of H2O2 Assay: A Mechanism and Application Study, Small, 2023, 2300444. (IF: 15.153)
联系方式
通讯地址：陕西省西安市中国西部科技创新港21号楼泓仁楼1091
电子邮箱: baojidu@xjtu.edu.cn
个人主页：https://gr.xjtu.edu.cn/en/web/baojidu
欢迎具有化学、生物学、材料学、医学、药学等专业背景的博士后和研究生同学加入！欢迎对科研感兴趣的本科生同学加入！
