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吕海侠
2016-07-08  
  吕海侠
 
研究领域或方向
1)神经干细胞的基础和应用研究;2)神经损伤修复;3)神经组织工程
工作简历
1990.7-2008.5 西安交通大学医学院第二附属医院妇产科医师

2008.5-2008.7 西安交通大学医学院神经生物学研究所 讲师

2008.8-2013.12 西安交通大学医学院神经生物学研究所副教授

2014.0至今 西安交通大学医学院神经生物学研究所教授

科研项目
近5年主持国家自然科学基金项目2项,国家重点实验室开放项目1项,其它项目3项
学术科研

发表科研论文41篇,SCI收录19篇,其中第一作者/通讯作者26篇,SCI收录12篇;参加国际学术会议交流9次。

近5年发表科研论文列表:

(1) Lu Hai-xia, Jiao Qian, Wang Yuan-yuan, Yang Zhi-qian, Feng Min-juan, Wang Li, Chen Xin-lin, Jin Wei-lin, Liu Yong*. The mental retardation associated protein srGAP3 regulates survival, proliferation and differentiation of rat embryonic neural stem/progenitor cells. Stem Cells Dev. 2013, 22(11):1709-1716.

(2) Jiao Qian, Xie Wu-ling, Wang Yuan-yuan, Chen Xin-lin, Yang Peng-bo, Zhang Peng-bo, Tan Jing, Lu Hai-xia*, Liu Yong*. Spatial relationship between NSCs/NPCs and microvessels in rat brain along prenatal and postnatal development. Int. J. Dev Neurosci. 2013; 31(4): 280-285

(3) Lu Xiao-yun, Wang Lei-lei, Yang Zhi-qian, Lu Hai-xia*. Strategies of polyhydroxyalkanoates modification for the medical application in neural regeneration/ nerve tissue engineering. Adv Biosci Biotechnol. 2013; 4:731-740

(4) Lu Hai-xia, Yang Zhi-qian, Jiao Qian, Wang Yuan-yuan, Wang Li, Yang Peng-bo, Chen Xin-lin, Zhang Peng-bo, Wang Peng, Chen Ming-xia, Lu Xiao-yun*, Liu Yong*. Low Concentration of Serum Helps to Maintain the Characteristics of NSCs/NPCs on Alkali Treated PHBHHx Film in Vitro. Neurol Res. 2014, 36(3): 207-214

(5) Lu Hai-xia, Searle Karren, Liu Yong*, and Parker Terry*. The effect of dimensionality on growth and differentiation of neural progenitors from different regions of fetal rat brain in vitro: 3-D spheroid versus 2-D monolayer cultures. Cells Tissues Organs. 2012; 196(1):48-55

(6) Lu Hai-xia, Hao Zhi-ming, Jiao Qian, Xie Wu-ling, Zhang Jun-feng, Lu Yi-fei, Cai Min, Parker Terry, Liu Yong*. Neurotrophin-3 gene transduction of mouse neural stem cells promotes proliferation and neuronal differentiation in organotypic hippocampal slice cultures. Med Sci Monit. 2011. 17 (10): BR305-311

(7) Lu hai-xia, Levis Hannah, Parker TL*. Organotypic slices culture model for cerebella ataxia: potential use to study Purkinje cell induction from neural stem cells. Brain Res Bul. 2011, 84(2): 169-173

(8)Lu Hai-xia, Jiao Qian, Xie Wu-ling, Zhang Jun-feng, Liu yong. NT-3 gene modification via AAV vector promotes mouse NSCs proliferation and neuronal differentiation in vitro. Int J Stroke. 2010, 5: 137 Abstract

(9)Yang Pengbo, Zhang Junfeng, Zhao Lingyu, Jiao Qian, Jin Hui, Xiao Xinli, Zhang Haixia, Hu Ming, Lu Haixia, Liu Yong*. Developmental distribution pattern of metabotropic glutamate receptor 5 in prenatal human hippocampus. Neurosci Bull. 2012, 28(6): 704–714

(10)Zhang Pengbo, Li Weisong, Li Ling, Wang Ning, Li Xu, Gao Ming, Zheng Juan, Lei Shan, Chen Xinlin, Lu Haixia and Liu Yong. Treatment with edaravone attenuates ischemic brain injury and inhibits neurogenesis in the subventricular zone of adult rats after focal cerebral ischemia and reperfusion injury. Neuroscience. 2012, 201: 297–306

(11)Xu Xi, Zhang Junfeng, Chen Xinlin, Liu Jianxin, Lu Haixia, Yang Pengbo, Xiao Xinli, Zhao Lingyu, Jiao Qian, Zhao Bingqiao, Zheng Ping, Liu Yong. The increased expression of metabotropic glutamate receptor 5 in subventricular zone neural progenitor cells and enhanced neurogenesis in a rat model of intracerebral hemorrhage. Neuroscience. 2012, 202: 474–483

(12)Yao Lu, Chen Xinlin, Tian Yingfang, Lu Haixia, Zhang Pengbo, Shi Qindong, Zhang Junfeng , Liu Yong. Selection of housekeeping genes for normalization of RT-PCR in hypoxic neural stem cells of rat in vitro. Mol Bio Rep. 2012, 39 (1):569-576

(13)Zhang Junfeng, Shi Qindong, Chen Xinlin, Yang Pengbo, Qi Cunfang, Zhang Jianshui, Lu Haixia, Liu Jianxin, Jiao Qian, Zhao Lingyu, Zhao Bingqiao, Pheng Ping and Liu Yong*. Hypoxia-regulated neurotrophin-3 expression by multicopy hypoxia response elements reduces apoptosis in PC12 cells. Int J Mol Med. 2012, 30(5):1173-1179

(14)Zhang Pengbo, Li Jie, Liu Yong, Chen Xinlin, Lu Haixia, Kang Qianyan, Li Weisong and Gao Ming. Human embryonic neural stem cell transplantation increases subventricular zone cell proliferation and promotes peri-infarct angiogenesis after focal cerebral ischemia. Neuropathology. 2011, 31(4): 384-391

(15) 王丽, 马辉, 焦倩, 王媛媛, 张志超, 杨蓬勃, 陈新林, 李昭荣*, 吕海侠*, 刘勇. 细胞因子信号转导抑制因子3激酶抑制区对STAT3磷酸化的抑制作用. 中国解剖学杂志. 2014, 37(2). 146-149

(16) 王丽, 王媛媛, 刘海莉, 李昭荣*, 吕海侠*. MicroRNA与神经系统发育的研究进展. 中南大学学报(医学版). 2013, 38 (3): 323-328

(17)冯敏娟, 吕海侠*, 王媛媛, 焦倩, 杨志倩, 王志荣, 邢兰英, 刘勇. 米非司酮对大鼠胚胎神经干细胞存活、增殖及分化的影响. 基础医学与临床. 2013,33(5): 537-541

(18)吕海侠, 杨志倩, 卢晓云, 李明川, 焦倩, 陈新林, 王媛媛, 张雅利. PHBHHx膜表面亲水改性及其与神经干细胞生物相容性. 生物工程学报. 2012, 28(9): 1216-1226

(19)卢晓云, 杨志倩, 吕海侠*, 焦倩, 王媛媛, 冯敏娟, 张雅利, 刘勇. 3-羟基丁酸对体外培养大鼠皮质神经干细胞增殖分化的影响. 西安交通大学学报. 2012, 33(6): 689-692

(20) 焦倩, 章海霞, 吕海侠*, 刘勇*. 新生大鼠器官型脑组织片培养以及诱导神经干细胞分化初步观察, 南方医科大学学报. 2011, 31(8): 1318-1322

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